TABLE 2

TNC of ¹⁷⁷Lu-DOTA-Tyr³-Octreotate, Measured at 1–7 Days After Injection* (3.3 MBq) and at 34 Days After Injection^† (60 and 120 MBq) and Calculated at Time of Minimal Relative Tumor Volume^‡ (60 and 120 MBq)

Tissue	Data from reference 21					Data from current work
		3.3 MBq (0.7 μg)^§ 1 dpi	3.3 MBq (0.7 μg)^§ 3 dpi	3.3 MBq (0.7 μg)^§ 7 dpi	Measured			Calculated
		3.3 MBq (0.7 μg)^§ 1 dpi	3.3 MBq (0.7 μg)^§ 3 dpi	3.3 MBq (0.7 μg)^§ 7 dpi				60 MBq (1.9 μg)^§ 34 dpi	120 MBq (3.7 μg)^§ 34 dpi	60 MBq (1.9 μg)^§ 15 dpi	120 MBq (3.7 μg)^§ 19 dpi
Blood	480 ± 130	620 ± 120	1,000 ± 340	¶
Heart	110 ± 27	120 ± 7.7	93 ± 27	9.4 ± 3.2	34 ± 5.4	47 ± 16	112 ± 18
Lungs	8.5 ± 3.1	5.9 ± 0.5	17 ± 5.1	5.1 ± 1.4	15 ± 3.5	26 ± 7.1	50 ± 4.6
Salivary glands	100 ± 30	120 ± 8.7	140 ± 43	19 ± 15	15 ± 0.9	96 ± 76	50 ± 2.6
Liver	38 ± 9.4	41 ± 2.1	17 ± 5.2	2.1 ± 0.4	11 ± 0.8	11 ± 2.0	36 ± 16
Pancreas	11 ± 3.6	18 ± 1.5	38 ± 12	9.6 ± 2.3	41 ± 4.8	48 ± 12	136 ± 16
Spleen	35 ± 11	30 ± 2.2	35 ± 15	2.2 ± 0.7	6.0 ± 0.4	11 ± 3.5	20 ± 1.3
Fat	33 ± 13	40 ± 4.9	32 ± 10	¶
Small intestine	31 ± 2.6	30 ± 2.6	41 ± 20	¶
Adrenals	12 ± 0.7	13 ± 1.0	9.7 ± 2.2	¶
Kidneys	2.0 ± 1.4	3.7 ± 0.3	4.1 ± 1.4	2.5 ± 0.7	9.1 ± 0.4	13 ± 3.5	30 ± 1.3
Muscle	410 ± 6.1	370 ± 35	910 ± 300	¶
Bone marrow	13 ± 6.1	30 ± 5.3	12 ± 4.4	1.2 ± 0.3	3.0 ± 1.0	6.1 ± 1.5	9.9 ± 3.3
Brain	300 ± 110	270 ± 12	280 ± 83	¶

↵* Results 1–7 d after injection (dpi) are based on published biodistribution data (21).
↵^† Results 34 dpi are from current study.
↵^‡ In this calculation, constant activity in tumor was assumed from time of minimal relative tumor volume (15 dpi for 60 MBq and 19 dpi for 120 MBq) to 34 dpi.
↵^§ Amount of peptide administered.
↵^¶ Data not obtained.
Data are given as mean ± SEM (n = 3–6).