Four-Hour and 24-Hour Tissue Distribution (%ID/g) of 64Cu-TP3982 Before and After Receptor Blocking in Mice Bearing T47D Tumors (n = 4)
| Tissue | 4 h | 24 h | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Before | After | P | Before | After | P | |||||
| Muscle | 1.77 ± 0.33 | 1.16 ± 0.19 | 0.01 | 2.68 ± 0.30 | 1.61 ± 0.39 | 0.00 | ||||
| Intestine | 8.31 ± 2.83 | 5.20 ± 0.59 | 0.01 | 8.97 ± 3.03 | 6.19 ± 0.63 | 0.02 | ||||
| Heart | 3.90 ± 1.07 | 2.89 ± 0.34 | 0.01 | 6.41 ± 1.92 | 4.37 ± 0.60 | 0.01 | ||||
| Lungs | 50.40 ± 8.06 | 5.36 ± 0.33 | 0.01 | 11.02 ± 5.13 | 7.12 ± 0.69 | 0.08 | ||||
| Blood | 2.27 ± 0.80 | 2.00 ± 0.15 | 0.01 | 2.80 ± 0.97 | 2.91 ± 0.29 | 0.75 | ||||
| Spleen | 4.12 ± 1.52 | 14.93 ± 4.01 | 0.01 | 4.74 ± 1.61 | 4.55 ± 1.15 | 0.77 | ||||
| Kidneys | 9.08 ± 3.23 | 5.78 ± 0.24 | 0.01 | 10.56 ± 3.59 | 8.38 ± 0.28 | 0.13 | ||||
| Liver | 25.69 ± 2.73 | 30.26 ± 3.59 | 0.12 | 21.15 ± 8.08 | 20.64 ± 1.84 | 0.88 | ||||
| Tumor | 10.81 ± 2.12 | 6.42 ± 1.14 | 0.02 | 17.04 ± 0.73 | 12.06 ± 2.87 | 0.01 | ||||
| T/M ratio | 6.42 ± 2.30 | 5.73 ± 1.79 | 0.83 | 6.43 ± 0.86 | 7.92 ± 3.26 | 0.34 | ||||
| T/B ratio | 5.96 ± 4.32 | 3.21 ± 0.50 | 0.19 | 6.99 ± 3.40 | 4.17 ± 1.00 | 0.03 | ||||
T/M ratio = tumor-to-muscle ratio; T/B ratio = tumor-to-blood ratio.