TABLE 1

Tissue Distribution (%ID/g) of ^99mTc-TP3654 and ^99mTc-TP3982 in Nude Mice Bearing T47D (n = 5)

Tissue	4 h					24 h
Tissue		^99mTc-TP3654	^99mTc-TP3982	P	^99mTc-TP3654	^99mTc-TP3982	P
Muscle	0.09 ± 0.01	0.29 ± 0.07	0.01	0.04 ± 0.01	0.17 ± 0.04	0.00
Intestine	0.18 ± 0.05	0.64 ± 0.15	0.01	0.05 ± 0.01	0.28 ± 0.03	0.00
Heart	0.10 ± 0.00	1.25 ± 0.11	0.01	0.06 ± 0.01	0.47 ± 0.03	0.00
Lungs	0.17 ± 0.01	0.90 ± 0.11	0.01	0.16 ± 0.09	0.54 ± 0.05	0.00
Blood	0.21 ± 0.02	0.82 ± 0.08	0.01	0.12 ± 0.02	0.23 ± 0.01	0.00
Spleen	0.19 ± 0.05	1.98 ± 0.38	0.01	0.11 ± 0.02	1.29 ± 0.08	0.00
Kidneys	18.99 ± 3.75	7.70 ± 1.26	0.01	3.52 ± 0.40	5.18 ± 0.45	0.01
Liver	1.12 ± 0.08	10.13 ± 1.69	0.01	0.33 ± 0.04	6.11 ± 0.50	0.00
Tumor	0.24 ± 0.08	0.51 ± 0.05	0.01	0.23 ± 0.13	0.77 ± 0.12	0.00
T/M ratio	2.73 ± 1.09	1.86 ± 0.59	0.01	6.28 ± 3.09	4.83 ± 1.31	0.05
T/B ratio	1.16 ± 0.29	0.63 ± 0.12	0.01	1.98 ± 1.44	3.29 ± 0.55	0.04

T/M ratio = tumor-to-muscle ratio; T/B ratio = tumor-to-blood ratio.