11C-Arachidonic Acid Incorporation Rate (K*)
| Region | Uncorrected | 2S-PVC | 3S-PVC | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Young | Old | P | Young | Old | P | Young | Old | P | ||||||||||
| Absolute values (μL/min/mL) | ||||||||||||||||||
| Frontal | 4.76 (25) | 4.21 (14) | 0.3 | 5.71 (30) | 5.36 (9) | 0.5 | 7.40 (31) | 6.83 (7) | 0.5 | |||||||||
| Temporal | 4.46 (23) | 4.23 (11) | 0.6 | 5.06 (25) | 5.09 (9) | 0.8 | 6.42 (27) | 6.25 (8) | 0.8 | |||||||||
| Parietal | 4.79 (24) | 4.40 (15) | 0.5 | 5.91 (26) | 5.77 (10) | 1.0 | 8.06 (29) | 8.07 (7) | 1.0 | |||||||||
| Occipital | 5.26 (26) | 4.99 (15) | 0.6 | 5.96 (28) | 5.87 (10) | 0.9 | 8.16 (29) | 8.34 (9) | 0.9 | |||||||||
| Caudate | 4.29 (29) | 3.81 (19) | 0.4 | 4.86 (29) | 4.53 (16) | 0.4 | 5.75 (29) | 5.18 (18) | 0.4 | |||||||||
| Putamen | 5.43 (26) | 4.88 (12) | 0.4 | 5.45 (26) | 4.99 (12) | 0.2 | 7.33 (26) | 6.33 (13) | 0.2 | |||||||||
| Thalamus | 5.02 (26) | 4.74 (13) | 0.6 | 5.31 (26) | 5.18 (11) | 0.7 | 6.10 (27) | 5.87 (11) | 0.7 | |||||||||
| Cerebellum | 5.41 (24) | 5.16 (13) | 0.6 | 5.93 (29) | 5.74 (13) | 0.5 | 7.75 (26) | 7.16 (11) | 0.5 | |||||||||
| Gray matter | 4.86 (24) | 4.51 (14) | 0.5 | 5.65 (27) | 5.45 (10) | 0.5 | 7.35 (28) | 7.03 (8) | 0.5 | |||||||||
| Values normalized to global gray matter | ||||||||||||||||||
| Frontal | 0.98 (2) | 0.93 (1) | 0.001* | 1.00 (4) | 0.98 (2) | 0.2 | 1.00 (4) | 0.97 (3) | 0.2 | |||||||||
| Temporal | 0.92 (3) | 0.95 (8) | 0.3 | 0.90 (5) | 0.93 (3) | 0.1 | 0.88 (4) | 0.89 (3) | 0.4 | |||||||||
| Parietal | 0.99 (2) | 0.97 (4) | 0.5 | 1.05 (5) | 1.06 (2) | 0.7 | 1.10 (5) | 1.15 (3) | 0.052 | |||||||||
| Occipital | 1.08 (4) | 1.10 (3) | 0.2 | 1.06 (4) | 1.08 (2) | 0.3 | 1.11 (5) | 1.19 (4) | 0.014* | |||||||||
| Caudate | 0.87 (8) | 0.85 (11) | 0.5 | 0.86 (10) | 0.83 (11) | 0.5 | 0.78 (11) | 0.74 (13) | 0.3 | |||||||||
| Putamen | 1.12 (4) | 1.09 (7) | 0.4 | 0.97 (6) | 0.92 (5) | 0.046* | 1.01 (8) | 0.90 (7) | 0.013* | |||||||||
| Thalamus | 1.03 (4) | 1.06 (5) | 0.3 | 0.94 (4) | 0.95 (4) | 0.7 | 0.83 (6) | 0.83 (5) | 1.0 | |||||||||
| Cerebellum | 1.12 (3) | 1.15 (2) | 0.08 | 1.05 (4) | 1.05 (4) | 0.9 | 1.06 (8) | 1.02 (5) | 0.2 | |||||||||
↵* Statistical significance for uncorrected P < 0.05 (unpaired t test between young and old).
Mean (% CV) for young (n = 8) and old (n = 7) healthy subjects of K* for 11C-AA in uncorrected images and after 2S-PVC and 3S-PVC.