Common Indications and Contraindications
| Indications | Contraindications |
|---|---|
| Multiple painful osseous metastases | Pregnancy; breastfeeding; women of child-bearing age |
| Skeletal metastasis involving >1 site that are positive (increased tracer uptake) on bone scintigraphy | Acute or chronic renal failure |
| Acute spinal cord suppression: needs external radiation therapy | |
| Hemoglobin < 90 g · L−1 | |
| Total white cell count < 3.5 × 109 L−1 | |
| Absolute neutrophil count < 1.5 × 109 L−1 | |
| Platelets < 60 × 109 L−1 | |
| Glomerular filtration rate < 30 mL/min |