TABLE 1

Mean Performance Levels in Neuropsychologic Assessment

Subject	Sex F:M	Age (y)	Education (y)	Years after baseline study	MMSE	Digit span			Word learning (10 words), delayed recall (30 min)	Story recall (15 elements)			Ray–Osterrieth complex figure test
						Digit span				Story recall (15 elements)									Copy	Recall
													Forward	Backward	Immediate	Delayed (30 min)	Immediate	Delayed (30 min)	Copy
Healthy volunteers	39:37	71.0 ± 7.1	12.0 ± 2.7		27.8 ± 2.4	5.3 ± 0.6	4.2 ± 0.7	8.0 ± 1.0	9.6 ± 3.6	8.0 ± 2.7	35.6 ± 0.8	19.9 ± 4.3	18.8 ± 5.6
Early AD patients	22:16	71.1 ± 8.4	11.9 ± 2.6
Baseline					26.1 ± 1.6*	5.3 ± 0.9	3.9 ± 0.8*	1.3 ± 2.2^†	5.0 ± 2.6^†	0.8 ± 1.7^†	33.5 ± 5.7*	7.9 ± 4.4^†	5.6 ± 4.9^†
1st follow-up				1.2 ± 0.3	22.0 ± 3.7^†^‡	5.2 ± 0.9	3.8 ± 0.9^†	1.2 ± 2.4^†	4.5 ± 2.1^†	0.5 ± 1.4^†	31.2 ± 8.0^†	6.8 ± 4.8^†	4.1 ± 4.9^†^§
2nd follow-up				2.3 ± 0.6	19.9 ± 5.3^†^‡	5.3 ± 1.1	3.5 ± 1.2^†	0.3 ± 1.1^†^‡	3.5 ± 2.4^†^‡	0.2 ± 1.1^†^§	29.2 ± 10.1^†^§	15.3 ± 5.2^†^‡	2.8 ± 4.2^†^‡

↵* Scores of AD patients differ from those of healthy volunteers, P < 0.05 (Student t test).
↵^† Scores of AD patients differ from those of healthy volunteers, P < 0.01 (Student t test).
↵^‡ Scores of 1st or 2nd follow-up study differ from baseline study, P < 0.01 (repeated measurement ANOVA with Dunnet test as posthoc multiple comparison).
↵^§ Scores of 1st or 2nd follow-up study differ from baseline study, P < 0.05 (repeated measurement ANOVA with Dunnet test as posthoc multiple comparison).
Data are mean ± SD in healthy volunteers (n = 76) or early AD patients (n = 38).