TABLE 3

Tissue Distributions of Intraperitoneally and Intravenously Administered 88Y-MN-14 in Nude Mice Bearing Intraperitoneal LS174T Colon Cancer Xenografts

AdministrationOrganMean ± SD (n = 5) %ID/g at following hour after injection of radioconjugate:
24487296192
IntraperitonealTumor90.8 ± 13.483.5 ± 29.0139.5 ± 22.9128.5 ± 26.5148.1 ± 89.4
Blood13.2 ± 1.312.4 ± 1.712.5 ± 1.211.3 ± 3.06.9 ± 2.2
Muscle0.9 ± 0.11.4 ± 0.21.2 ± 0.20.9 ± 0.11.0 ± 0.5
Lungs7.9 ± 1.211.3 ± 1.510.0 ± 1.010.5 ± 2.07.2 ± 2.3
Spleen4.9 ± 0.85.2 ± 0.55.8 ± 0.85.9 ± 0.97.9 ± 1.3
Kidneys4.0 ± 0.34.2 ± 0.43.9 ± 0.43.3 ± 0.61.6 ± 1.5
Liver6.6 ± 0.66.7 ± 1.17.4 ± 1.36.8 ± 1.34.8 ± 3.1
Intestine2.9 ± 0.72.5 ± 0.52.0 ± 0.11.7 ± 0.31.7 ± 0.3
Femur0.9 ± 0.21.3 ± 0.52.0 ± 0.41.3 ± 0.22.4 ± 0.7
IntravenousTumor27.4 ± 9.4105.3 ± 50.5130.5 ± 49.9115.1 ± 5.4104.3 ± 55.9
Blood15.6 ± 0.813.6 ± 0.812.2 ± 1.09.8 ± 1.54.9 ± 3.0
Muscle1.0 ± 0.21.2 ± 0.11.3 ± 0.22.3 ± 2.60.6 ± 0.3
Lungs8.8 ± 1.28.0 ± 0.99.4 ± 1.98.0 ± 1.44.7 ± 2.4
Spleen5.1 ± 0.96.8 ± 0.46.4 ± 0.95.8 ± 0.67.1 ± 0.8
Kidneys4.4 ± 0.24.1 ± 0.23.9 ± 0.33.8 ± 0.52.3 ± 0.9
Liver9.5 ± 0.89.8 ± 0.69.4 ± 0.910.1 ± 1.98.9 ± 2.2
Intestine3.6 ± 0.82.0 ± 0.42.5 ± 0.41.9 ± 0.70.9 ± 0.3
Femur0.6 ± 0.32.0 ± 0.52.6 ± 0.31.5 ± 0.22.1 ± 0.8