Tissue Distributions of Intraperitoneally and Intravenously Administered 186Re-MN-14 in Nude Mice Bearing Intraperitoneal LS174T Colon Cancer Xenografts
| Administration | Organ | Mean ± SD (n = 5) %ID/g at following hour after injection of radioconjugate: | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 24 | 48 | 72 | 96 | 192 | ||||||
| Intraperitoneal | Tumor | 29.9 ± 7.3 | 77.8 ± 31.4 | 83.4 ± 18.5 | 66.0 ± 5.4 | 50.3 ± 29.2 | ||||
| Blood | 14.8 ± 1.0 | 12.7 ± 0.7 | 11.4 ± 0.8 | 8.9 ± 1.1 | 4.4 ± 2.7 | |||||
| Muscle | 1.24 ± 0.4 | 1.2 ± 0.1 | 1.2 ± 0.1 | 1.6 ± 1.4 | 0.5 ± 0.2 | |||||
| Lungs | 8.3 ± 1.2 | 7.0 ± 0.8 | 8.4 ± 1.5 | 6.6 ± 1.1 | 3.8 ± 2.2 | |||||
| Spleen | 3.8 ± 0.7 | 3.5 ± 0.4 | 3.2 ± 0.4 | 2.3 ± 0.5 | 1.6 ± 0.6 | |||||
| Kidneys | 4.3 ± 0.2 | 3.7 ± 0.2 | 3.4 ± 0.1 | 3.2 ± 0.4 | 1.7 ± 0.7 | |||||
| Liver | 5.2 ± 0.7 | 4.8 ± 0.3 | 4.6 ± 0.5 | 3.9 ± 0.5 | 2.0 ± 0.7 | |||||
| Intestine | 3.5 ± 0.8 | 1.8 ± 0.3 | 2.1 ± 0.4 | 1.5 ± 0.5 | 0.7 ± 0.3 | |||||
| Femur | 0.8 ± 0.1 | 1.1 ± 0.2 | 1.2 ± 0.2 | 0.7 ± 0.2 | 0.6 ± 0.2 | |||||
| Intravenous | Tumor | 58.1 ± 18.4 | 50.3 ± 21.1 | 68.2 ± 10.7 | 65.1 ± 14.2 | 67.8 ± 42.3 | ||||
| Blood | 12.8 ± 3.0 | 11.9 ± 1.36 | 11.2 ± 1.1 | 10.6 ± 2.2 | 6.14 ± 1.9 | |||||
| Muscle | 0.9 ± 0.2 | 1.2 ± 0.1 | 1.0 ± 0.1 | 0.8 ± 0.1 | 0.7 ± 0.4 | |||||
| Lungs | 7.8 ± 2.4 | 10.5 ± 1.1 | 8.5 ± 0.8 | 9.6 ± 1.3 | 5.8 ± 1.8 | |||||
| Spleen | 3.8 ± 1.1 | 3.2 ± 0.3 | 2.8 ± 0.3 | 2.5 ± 0.2 | 1.9 ± 0.4 | |||||
| Kidneys | 3.8 ± 0.8 | 3.8 ± 0.3 | 3.3 ± 0.4 | 2.9 ± 0.3 | 1.5 ± 1.0 | |||||
| Liver | 5.4 ± 1.2 | 4.7 ± 0.3 | 4.5 ± 0.8 | 3.5 ± 0.5 | 1.6 ± 1.1 | |||||
| Intestine | 2.8 ± 0.9 | 2.2 ± 0.3 | 1.7 ± 0.1 | 1.4 ± 0.1 | 1.2 ± 0.2 | |||||
| Femur | 0.9 ± 0.4 | 0.8 ± 0.4 | 1.0 ± 0.2 | 0.5 ± 0.1 | 0.5 ± 0.1 | |||||