TABLE 3

Biodistribution Results of 123I-ChiB_E144Q in Noninfected NMRI Mice

Biodistribution20 min1 h4 h9 h24 h48 h
Blood14.23 ± 3.8013.37 ± 1.015.09 ± 1.543.62 ± 0.430.83 ± 0.110.20 ± 0.03
Brain0.29 ± 0.120.30 ± 0.080.18 ± 0.150.11 ± 0.020.03 ± 0.030.03 ± 0.04
Heart3.80 ± 1.434.89 ± 1.851.40 ± 0.531.17 ± 0.400.35 ± 0.060.18 ± 0.13
Lung5.01 ± 3.595.86 ± 1.401.86 ± 0.700.92 ± 1.170.42 ± 0.110.14 ± 0.04
Stomach1.96 ± 1.304.89 ± 3.138.78 ± 4.106.64 ± 6.670.55 ± 0.120.11 ± 0.12
Spleen3.69 ± 0.553.18 ± 0.231.23 ± 0.510.95 ± 0.050.22 ± 0.030.09 ± 0.06
Liver2.32 ± 0.431.92 ± 0.900.99 ± 0.360.66 ± 0.120.19 ± 0.010.07 ± 0.01
Kidneys5.23 ± 1.855.20 ± 0.932.18 ± 0.551.39 ± 0.270.45 ± 0.280.18 ± 0.09
Small intestine0.72 ± 0.201.54 ± 0.111.00 ± 0.210.50 ± 0.570.14 ± 0.010.04 ± 0.02
Large intestine0.52 ± 0.200.79 ± 0.210.88 ± 0.040.65 ± 0.710.11 ± 0.050.05 ± 0.01
Bladder6.40 ± 4.401.62 ± 0.382.93 ± 2.011.57 ± 1.140.44 ± 0.330.44 ± 0.31
Fatty tissue1.55 ± 0.531.19 ± 1.121.16 ± 0.890.53 ± 0.220.22 ± 0.060.10 ± 0.03
  • Data are expressed as %ID/g ± SD (n = 3 mice/group). Represented data are a selection from 19 different time points ranging from 20 s to 48 h.