TABLE 1

Results of Series 2 Biodistribution Studies

GroupBATBloodBrainHeartLungLiverKidneySpleenStomachIntestineMuscleWAT
Control2.8 ± 0.410.059 ± 0.00450.46 ± 0.0500.46 ± 0.0780.13 ± 0.00760.087 ± 0.00810.22 ± 0.0250.18 ± 0.0200.13 ± 0.00770.28 ± 0.0250.065 ± 0.0110.048 ± 0.0030
Propranolol0.45* ± 0.140.071* ± 0.00620.62 ± 0.0670.14* ± 0.0130.10* ± 0.00580.098 ± 0.00670.23 ± 0.0180.11* ± 0.00790.12 ± 0.0110.23 ± 0.0180.027* ± 0.004*0.025* ± 0.0022
Reserpine0.79* ± 0.180.091* ± 0.00830.50 ± 0.0760.19* ± 0.00850.14 ± 0.00230.13* ± 0.00920.28 ± 0.0450.16 ± 0.0200.17 ± 0.0240.32 ± 0.0740.059 ± 0.0150.033* ± 0.0041
Diazepam1.8 ± 0.220.048* ± 0.00270.58 ± 0.0490.69* ± 0.0290.12 ± 0.00790.070 ± 0.00440.29 ± 0.0530.19 ± 0.0140.15 ± 0.00670.30 ± 0.0360.041 ± 0.00500.047 ± 0.0079
  • * P < 0.05 vs. control values.

  • Data are %ID/(g of tissue) × (kg of body weight) (mean ± SD).