Selected Biologic Prognostic Factors
| Biologic parameter | Adverse finding |
|---|---|
| Tumor cell features | |
| MYCN oncogene | >10 copies |
| Chromosome 17q | Gain |
| Chromosome 1p36 | Loss of heterozygosity |
| Chromosome 11q14-22 | Loss of heterozygosity |
| Chromosomal ploidy | Near diploid or near tetraploid |
| trkA | Absent or low expression |
| trkB | High expression |
| trkC | Absent or low expression |
| Telomerase | Increased activity or high expression |
| CD44 | Low expression |
| Shimada histopathology | Unfavorable by Shimada criteria |
| Biochemical marker | |
| Serum lactate dehydrogenase | >1,500 U/L |
| Serum neuron-specific enolase | >100 ng/mL |
| Serum ferritin | >142 ng/mL |
| Urine VMA:HVA ratio | <1 |
Data are from (20,40).