TABLE 4

Biodistribution in Tumored Mice 3 Hours After Administration of ^99mTc-MORF (Study 3)

Organ	Study: amplification	Control I: polymer only	Control II: radiolabeled polymer only	P value*	P value*
	[1]	[2]	[3]	[1] vs. [2]	[1] vs. [3]
Liver	0.64 ± 0.04	0.41 ± 0.07	0.44 ± 0.15	0.040	0.069
Heart	0.22 ± 0.02	0.16 ± 0.00	0.14 ± 0.03	0.046	0.008
Kidney	13.8 ± 4.3	15.4 ± 2.5	11.8 ± 0.90	0.365	0.878
Lung	0.50 ± 0.07	0.38 ± 0.01	0.33 ± 0.10	0.027	0.078
Spleen	0.76 ± 0.21	0.69 ± 0.06	0.23 ± 0.11	0.224	0.020
Muscle	0.18 ± 0.05	0.17 ± 0.18	0.05 ± 0.01	0.815	0.022
Tumor	0.65 ± 0.13	0.24 ± 0.04	0.18 ± 0.07	0.001	0.005
Blood	0.67 ± 0.06	0.31 ± 0.01	0.22 ± 0.05	0.006	0.004

Study animals (amplification targeting) received unlabeled antibody 51 h earlier and unlabeled polymer 21 h earlier (Fig. 1). Control I animals did not receive antibody. Control II animals received neither antibody nor polymer.
↵* Student t test for significance, P < 0.05 (statistically significant values are underlined).
Data are expressed as average %ID/g ± SD; n = 4.