Biodistribution in Tumored Mice (Study 1)
| Organ | Study (111In-antibody, 99mTc-polymer) | 99mTc-polymer only | P value* | ||
|---|---|---|---|---|---|
| 111In | 99mTc [1] | 99mTc [2] | [1] vs. [2] | ||
| Liver | 9.20 ± 0.74 | 29.1 ± 1.7 | 29.4 ± 1.0 | 0.745 | |
| Heart | 1.36 ± 0.33 | 0.66 ± 0.04 | 0.77 ± 0.10 | 0.091 | |
| Kidney | 12.2 ± 0.62 | 5.28 ± 0.84 | 5.36 ± 0.79 | 0.888 | |
| Lung | 2.12 ± 0.10 | 0.43 ± 0.09 | 0.40 ± 0.06 | 0.646 | |
| Spleen | 3.96 ± 0.63 | 12.7 ± 2.0 | 11.8 ± 0.98 | 0.419 | |
| Muscle | 0.68 ± 0.02 | 0.15 ± 0.04 | 0.16 ± 0.04 | 0.566 | |
| Tumor | 11.0 ± 0.57 | 1.17 ± 0.17 | 0.77 ± 0.10 | 0.002 | |
| Blood | 3.46 ± 0.40 | 0.32 ± 0.03 | 0.21 ± 0.04 | 0.004 | |
Study animals received 111In-labeled antibody 48 h earlier. Control animals did not receive antibody and received only labeled polymer 18 h earlier.
↵* Student t test for significance, P < 0.05 (statistically significant values are underlined).
Data are expressed as average %ID/g ± SD; n = 8.