Biodistribution in Tumored Mice 18 Hours After Administration of 99mTc-cMORF Polymer
| Organ | Polymer | Control | P value* | ||||
|---|---|---|---|---|---|---|---|
| 76 μg | 52 μg | 24 μg | |||||
| [1] | [2] | [1] vs. [2] | |||||
| Liver | 34.7 ± 0.95 | 34.2 ± 0.18 | 36.7 ± 2.9 | 32.8 ± 1.8 | 0.092 | ||
| Heart | 0.60 ± 0.30 | 1.01 ± 0.09 | 0.92 ± 0.24 | 0.71 ± 0.11 | 0.059 | ||
| Kidney | 4.85 ± 2.4 | 5.19 ± 0.40 | 7.99 ± 1.6 | 5.44 ± 2.0 | 0.153 | ||
| Lung | 0.38 ± 0.12 | 0.43 ± 0.07 | 0.56 ± 0.09 | 0.39 ± 0.08 | 0.099 | ||
| Spleen | 11.9 ± 8.0 | 15.2 ± 1.6 | 15.9 ± 1.6 | 14.9 ± 1.2 | 0.416 | ||
| Muscle | 0.16 ± 0.09 | 0.19 ± 0.02 | 0.17 ± 0.01 | 0.18 ± 0.04 | 0.834 | ||
| Tumor | 1.19 ± 0.10 | 1.31 ± 0.22 | 1.92 ± 0.16 | 0.75 ± 0.03 | 0.001 | ||
| Blood | 0.29 ± 0.08 | 0.41 ± 0.04 | 0.58 ± 0.07 | 0.21 ± 0.03 | 0.002 | ||
Animals received 76, 52, or 24 μg of polymer at 66 h after administration of 60 μg of MORF-antibody. Control animals received 24 μg of polymer but did not receive antibody.
↵* Student t test for significance, P < 0.05 (statistically significant values are underlined).
Data are expressed as average %ID/g ± SD; n = 4.