TABLE 3

Biodistribution Results (%ID/g tissue) for ¹²³I-mAb 14C5 in NMRI Mice (n = 3)

Tissue	Biodistribution time (h)
Tissue		0.083	0.33	1	3	6	9	15	24	48
Blood	51.13 ± 2.38	48.19 ± 4.38	38.62 ± 1.02	31.28 ± 2.06	27.02 ± 2.09	21.51 ± 2.54	16.01 ± 3.91	14.33 ± 3.06	13.31 ± 1.39
Brain	1.26 ± 0.26	0.93 ± 0.02	0.90 ± 0.25	0.71 ± 0.08	0.66 ± 0.17	0.46 ± 0.18	0.32 ± 0.15	0.28 ± 0.05	0.27 ± 0.08
Heart	8.08 ± 1.94	8.74 ± 2.13	7.96 ± 0.74	4.24 ± 3.56	6.81 ± 1.78	5.23 ± 1.82	3.57 ± 1.21	2.98 ± 0.59	2.42 ± 0.05
Lungs	20.39 ± 3.74	20.29 ± 11.55	16.69 ± 3.58	10.96 ± 3.58	7.83 ± 1.01	6.24 ± 1.50	4.91 ± 1.41	4.00 ± 1.09	3.46 ± 1.06
Stomach	5.72 ± 3.37	6.88 ± 2.12	7.35 ± 2.98	12.78 ± 2.44	11.51 ± 7.49	5.99 ± 2.93	0.87 ± 0.06	1.10 ± 0.25	1.02 ± 0.68
Spleen	8.45 ± 0.41	9.21 ± 2.36	6.69 ± 0.50	5.79 ± 0.84	4.78 ± 0.79	3.73 ± 0.38	3.01 ± 1.14	2.27 ± 0.39	2.13 ± 0.80
Liver	15.12 ± 1.40	14.24 ± 0.65	10.58 ± 1.35	9.17 ± 0.96	7.95 ± 1.57	5.91 ± 0.59	3.68 ± 1.46	3.15 ± 0.31	2.69 ± 0.55
Kidneys	11.13 ± 1.07	9.57 ± 0.81	9.16 ± 0.93	7.88 ± 0.67	6.21 ± 0.63	4.66 ± 1.18	3.32 ± 1.21	2.99 ± 0.66	2.62 ± 0.17
Small intestines	2.01 ± 0.48	2.17 ± 0.39	3.11 ± 0.20	3.67 ± 0.06	3.30 ± 0.89	2.27 ± 0.24	1.23 ± 0.37	1.12 ± 0.25	0.92 ± 0.23
Large intestines	1.12 ± 0.32	1.04 ± 0.21	1.32 ± 0.16	2.17 ± 0.22	2.39 ± 0.53	1.96 ± 0.37	0.93 ± 0.25	0.84 ± 0.06	0.80 ± 0.19
Bladder	2.29 ± 0.82	2.67 ± 0.72	3.48 ± 2.50	5.76 ± 3.52	8.68 ± 5.16	7.68 ± 2.68	4.26 ± 1.14	3.74 ± 0.72	3.43 ± 2.61
Body remainder	3.44 ± 0.48	3.28 ± 0.57	3.66 ± 0.48	4.10 ± 0.40	4.11 ± 0.23	3.46 ± 0.25	2.79 ± 0.45	2.90 ± 0.21	2.81 ± 0.29
Excretion*	0.15 ± 0.24	0.24 ± 0.62	3.38 ± 1.75	7.22 ± 0.81	13.76 ± 3.00	28.03 ± 3.41	45.98 ± 9.64	43.55 ± 6.75	48.05 ± 5.24

↵* Excretion values (urine + feces) are expressed as %ID.