TABLE 2

Kinetic Parameters for Blood Clearance of 123I-mAb 14C5 in Mice

ParameterAverageSD
Aα20.292.45
t1/2,α (h)1.430.42
Aβ12.032.41
t1/2,β (h)130.42100.00
r20.95
  • Aα and Aβ represent activity fractions (%ID) in blood at any time (T) after tracer injection, corresponding to biologic half-lives t1/2,α and t1/2,β, respectively.

  • Clearance data were fit to the following equation using method of least squares: Embedded Image