TABLE 2
Kinetic Parameters for Blood Clearance of 123I-mAb 14C5 in Mice
| Parameter | Average | SD |
|---|---|---|
| Aα | 20.29 | 2.45 |
| t1/2,α (h) | 1.43 | 0.42 |
| Aβ | 12.03 | 2.41 |
| t1/2,β (h) | 130.42 | 100.00 |
| r2 | 0.95 |
Aα and Aβ represent activity fractions (%ID) in blood at any time (T) after tracer injection, corresponding to biologic half-lives t1/2,α and t1/2,β, respectively.
Clearance data were fit to the following equation using method of least squares:
