TABLE 2

SPM Results for Group Comparison (2-Sample t Test): IPD Patients vs. Healthy Subjects, MSA Patients vs. Healthy Subjects, and IPD Patients vs. MSA Patients

Cluster level	Voxel level			Coordinates				Region (BA)
P_corr (uncorr)	k_E	P_corr (uncorr)	t	x	y	z		Region (BA)
IPD patients vs. healthy subjects
IPD patients < healthy subjects
<0.001	5,229	<0.001	10	30	25	43	R middle frontal gyrus (BA 8)
		<0.001	9.59	15	−11	6	R thalamus (ventral lateral nucleus)
		<0.001	9.24	24	9	0	R lentiform nucleus, putamen + cluster also includes homonymous L-sided structures
<0.001	745	<0.001	9.38	−30	−62	47	L superior parietal lobule (BA 7)
		<0.001	7.31	−12	−47	47	L parietal lobe, precuneus (BA 7)
<0.001	1,495	<0.001	8.07	36	−53	47	R inferior parietal lobule (BA 40)
		<0.001	8.02	9	−33	43	R parietal lobe, precuneus (BA 7)
		<0.001	7.99	42	−47	47	R inferior parietal lobule (BA 40)
<0.001	166	<0.001	6.63	62	−29	−1	R middle temporal gyrus (BA 21)
IPD patients > healthy subjects
0.005	805	0.04	4.52	9	−50	−8	Vermis
		0.14 (<0.001)	4.02	33	−62	−15	R upper cerebellar hemisphere
		0.16 (<0.001)	4.11	50	−59	−22	R upper cerebellar hemisphere
MSA patients vs. healthy subjects
MSA patients < healthy subjects
<0.001	2,098	<0.001	9.01	30	0	0	R lentiform nucleus, putamen
		<0.001	7.98	−33	0	3	L lentiform nucleus, putamen, claustrum
		<0.001	6.97	15	−14	6	R (+ L) thalamus, ventral lateral nucleus
<0.001	381	<0.001	6.22	50	22	29	R middle frontal gyrus (BA 9)
		<0.001	5.71	30	11	52	R middle frontal gyrus (BA 6)
		<0.001	5.17	33	20	46	R middle frontal gyrus (BA 8)
IPD patients vs. MSA patients
MSA patients < IPD patients
0.008	723	<0.001	5.79	33	−6	−2	R lentiform nucleus, putamen, claustrum
		0.01	4.93	39	8	−5	R insula (BA 13)
(0.042)	227	0.05	4.43	−33	0	0	L claustrum, lentiform nucleus, putamen

Corr = corrected; uncorr = uncorrected.