TABLE 1

Validation of Quantitative Measurements of LVEF by Different Software Programs for Gated Myocardial Perfusion SPECT

Authors	Year	Software	Gold standard	No. of patients	r	Isotope	Reference
Ioannidis et al.	2002	QGS	MRI		0.89		62
Baba et al.	2002	QGS	Contrast ventriculography	20	0.80	²⁰¹Tl	63
Itti et al.	2001	QGS	ERNA	50	0.88–0.92	²⁰¹Tl	64
Vourvouri et al.	2001	QGS	2D Echo	32	0.83		65
Higuchi et al.	2001	QGS	ERNA		0.90		66
Germano et al.	1995	QGS	FPRNA	65	0.90	^99mTc-Sestamibi	10
Faber et al.	1999	ECTb	MRI	10	0.88	^99mTc-Sestamibi	67
			FPRNA	79	0.82
Vallejo et al.	2000	QGS	MRI	16 (canine)	0.51	^99mTc-Sestamibi	13
Tadamura et al.	1999	QGS	MRI	20	0.92	²⁰¹Tl	68
					0.94	^99mTc-Sestamibi
Yoshioka et al.	1999	QGS	FPRNA	21	0.91	^99mTc-Tetrofosmin	69
					0.87
Vallejo et al.	2000	QGS	FPRNA	400	0.66		14
Nichols et al.	1998		LV angiography	58	0.86	^99mTc-Sestamibi	70
Nichols et al.	1997		FPRNA	22	0.90	^99mTc-Sestamibi	71
Atsma et al.	2000	QGS	Contrast ventriculography	74	0.84	^99mTc-Tetrofosmin	72
Wright et al.	2000	QGS	ERNA	70	0.70–0.71	²⁰¹Tl (low dose)	73
Bax et al.	2000	QGS	MRI	22	0.90	^99mTc-Tetrofosmin	74
Bavelaar-Croon et al.	2000	QGS	MRI	21	0.85		75
Cwajg et al.	2000		2D Echo	109	≥0.68	²⁰¹Tl	76
						^99mTc
Nichols et al.	2000	SPECT	2D Echo	33	0.92 overall		77
		EF			0.82 SPECT EF
		QGS			0.75 QGS
		ECTb			0.72 ECTb
He et al.	1999		FPRNA	63	0.84–0.85	^99mTc-Sestamibi	78
						²⁰¹Tl
Vaduganathan et al.	1999		MRI	25	0.93	^99mTc	79
Inubushi et al.	1999	QGS	FPRNA	44	0.919	^99mTc-Sestamibi	80
Nichols et al.	1996		ERNA	75	0.87	^99mTc-Sestamibi	81
			FPRNA	65	0.87
Nakajima et al.	2001	QGS	ERNA	30	0.82 QGS		18
		ECTb			0.78 ECTb
		4D-MSPECT			0.69 4D-MSPECT
		pFAST*			0.84 pFAST*
Everaert et al.	1997	QGS	ERNA	40	0.89 QGS	^99mTc-Tetrofosmin	82
		Stanford			0.93 SU
Chua et al.	2000	QGS	ERNA	62	0.94	^99mTc	83
Abe et al.	2000	QGS	Contrast ventriculography	229	0.78	^99mTc-Tetrofosmin	84
Manrique et al.	2000	QGS	ERNA	55	0.71–0.94	²⁰¹Tl	85
Williams and Taillon	1996	University of Chicago image inversion	FPRNA	38	0.83	^99mTc-Sestamibi	86
Williams and Taillon		University of Chicago image inversion			Contrast ventriculography	54	0.93

↵* Perfusion and function analysis for gated SPECT.
ERNA = equilibrium radionuclide angiography; 2D Echo = 2-dimensional echocardiography; FPRNA = first-pass radionuclide angiography.