TABLE 1

Percentage Injected Dose in Rats of syn- and anti-99mTc-d- and l-MAEC Isomers in Blood, Urine, and Selected Organs at 10 and 60 Minutes Compared with 131I-OIH

IsomerBloodKidneyUrineUrineLiverBowel
99mTc131I-OIH99mTc131I-OIH99mTc131I-OIH% 99mTc/131I-OIH99mTc131I-OIH99mTc131I-OIH
d-MAEC
anti, 10 min8.1 ± 1.14.3 ± 1.05.8 ± 0.34.3 ± 0.442.6 ± 5.059.2 ± 7.4726.8 ± 1.12.3 ± 0.83.3 ± 0.70.9 ± 0.5
anti, 60 min3.2 ± 0.20.6 ± 0.13.3 ± 0.20.4 ± 0.275.0 ± 4.589.4 ± 7.5841.3 ± 0.00.4 ± 0.25.0 ± 1.80.8 ± 0.2
syn, 10 min8.5 ± 2.25.3 ± 1.25.2 ± 3.75.4 ± 4.037.7 ± 6.748.1 ± 5.6787.9 ± 4.32.9 ± 1.13.2 ± 0.21.6 ± 0.5
syn, 60 min0.6 ± 0.20.6 ± 0.10.8 ± 0.30.3 ± 0.285.1 ± 9.791.9 ± 7.2930.8 ± 0.30.3 ± 0.23.1 ± 0.80.7 ± 0.1
l-MAEC
anti, 10 min4.6 ± 0.64.4 ± 0.614.9 ± 2.55.7 ± 2.145.4 ± 6.058.8 ± 10.5774.8 ± 0.92.8 ± 0.62.7 ± 0.51.0 ± 0.3
anti, 60 min0.5 ± 0.10.6 ± 0.14.3 ± 0.70.4 ± 0.283.0 ± 4.391.3 ± 4.6911.2 ± 0.20.4 ± 0.25.8 ± 3.60.8 ± 0.3
syn, 10 min4.3 ± 0.94.3 ± 0.410.8 ± 2.46.8 ± 2.249.4 ± 7.856.7 ± 7.0872.6 ± 0.62.2 ± 0.41.6 ± 0.21.1 ± 0.2
syn, 60 min0.5 ± 0.70.7 ± 0.42.2 ± 0.40.5 ± 0.578.6 ± 23.478.9 ± 24.4990.3 ± 0.20.5 ± 0.21.7 ± 0.60.8 ± 0.2
  • n = 5 for each data point with exception of anti-99mTc-d-MAEC at 10 min, where n = 3, and anti-99mTc-d-MAEC at 60 min, where n = 4.

  • Data are presented as mean ± SD.