Biodistribution of Radioactivity After Administration of 11C-5MA
| Biodistribution | Time after injection (min) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 2 | 5 | 15 | 30 | 60 | |||||
| Blood | 1.73 ± 0.35 | 1.35 ± 0.02 | 1.09 ± 0.06 | 0.83 ± 0.11 | 0.42 ± 0.02 | ||||
| Intestine | 3.08 ± 0.58 | 3.22 ± 0.56 | 2.47 ± 0.13 | 2.44 ± 0.34 | 1.90 ± 0.39 | ||||
| Liver | 7.29 ± 1.30 | 7.80 ± 0.36 | 5.53 ± 0.33 | 4.09 ± 0.52 | 2.34 ± 0.24 | ||||
| Kidney | 20.0 ± 3.99 | 18.2 ± 0.19 | 21.6 ± 4.21 | 6.94 ± 1.09 | 4.88 ± 0.93 | ||||
| Stomach | 2.01 ± 0.17 | 2.79 ± 0.34 | 2.56 ± 0.13 | 3.52 ± 0.52 | 2.19 ± 1.00 | ||||
| Spleen | 3.31 ± 0.68 | 5.46 ± 0.97 | 4.28 ± 0.52 | 4.14 ± 1.83 | 1.57 ± 0.82 | ||||
| Pancreas | 7.77 ± 1.08 | 7.00 ± 1.23 | 3.30 ± 0.12 | 1.93 ± 0.22 | 0.88 ± 0.24 | ||||
| Heart | 4.87 ± 1.60 | 2.94 ± 0.51 | 1.53 ± 0.21 | 1.12 ± 0.30 | 0.62 ± 0.34 | ||||
| Lung | 7.14 ± 2.46 | 5.78 ± 0.78 | 2.42 ± 0.46 | 1.54 ± 0.29 | 0.94 ± 0.32 | ||||
| Brain | 1.23 ± 0.12 | 1.66 ± 0.09 | 2.24 ± 0.12 | 2.19 ± 0.24 | 1.87 ± 0.21 | ||||
| Br/Bl* | 0.71 ± 0.15 | 1.23 ± 0.07 | 2.06 ± 0.19 | 2.65 ± 0.23 | 4.28 ± 0.46 | ||||
↵* Br/Bl = brain-to-blood ratio (percentage of injected 11C dose/gram of organ ratio).
Biodistribution of radioactivity is expressed as percentage of injected 11C dose/gram of organ (mean ± SD for 4 mice).