TABLE 1

Ki Values for Inhibiting (−)-3H-Cytisine Binding to Rat Brain Synaptosomal Membranes

CompoundKi (nmol/L)
5MA0.27 ± 0.16*
A-853800.38 ± 0.01*
(−)-Cytisine0.92 ± 0.42*
(−)-Nicotine2.71 ± 0.73*
Acetylcholine13.40 ± 2.61*
Mecamylamine>1,000,000†
α-Bungarotoxin>1,000,000†

  • ↵* Mean ± SD of 3 independent experiments.

  • ↵† Not inhibited at the highest concentration tested (10−4 mol/L).