Tissue | Model 1: assuming complete local β-ray absorption | Model 2: using equal spheric organ mass assumption | ||||||
---|---|---|---|---|---|---|---|---|
90Y-DOTA-biotin 5F11-scFv-SA (μg) | 131I-3F8 | 90Y-DOTA-biotin 5F11-scFv-SA (μg) | ||||||
300 | 900 | 300 | 900 | |||||
Bladder | 1.9 ± 0.3 | 4.1 ± 0.6 | 8.5 ± 1.8 | 0.4 ± 0.1 | 0.8 ± 0.1 | |||
Blood | 1.3 ± 0.6 | 0.9 ± 0.6 | 89.2 ± 37.2 | NA | NA | |||
Bone | 0.9 ± 0.0 | 1.1 ± 0.2 | 8.7 ± 1.4 | NA | NA | |||
Brain | 0.8 ± 0.2 | 0.9 ± 0.1 | 3.1 ± 1.3 | 0.5 ± 0.1 | 0.5 ± 0.0 | |||
Heart | 1.2 ± 0.2 | 1.4 ± 0.2 | 23.6 ± 2.1 | 0.6 ± 0.1 | 0.8 ± 0.1 | |||
Kidney | 30.6 ± 4.8 | 50.4 ± 6.7 | 18.0 ± 3.1 | 16.1 ± 2.5 | 26.5 ± 3.5 | |||
Large intestine | 4.5 ± 0.5 | 14.6 ± 2.2 | 7.1 ± 1.1 | 3.4 ± 0.3 | 10.8 ± 1.6 | |||
Liver | 5.1 ± 0.7 | 7.2 ± 0.2 | 12.4 ± 2.4 | 3.9 ± 0.5 | 5.6 ± 0.2 | |||
Lung | 3.2 ± 1.4 | 5.2 ± 1.0 | 28.6 ± 3.4 | 1.6 ± 0.7 | 2.7 ± 0.5 | |||
Small intestine | 1.1 ± 0.3 | 1.8 ± 0.6 | 10.7 ± 0.2 | 0.9 ± 0.2 | 1.4 ± 0.5 | |||
Spleen | 2.1 ± 0.2 | 2.3 ± 0.2 | 17.9 ± 1.3 | 1.1 ± 0.1 | 1.2 ± 0.1 | |||
Stomach | 1.5 ± 0.3 | 1.4 ± 0.2 | 10.2 ± 6.0 | 0.8 ± 0.1 | 0.7 ± 0.1 | |||
Tumor | 77.0 ± 11.2 | 153.1 ± 8.3 | 237.4 ± 40.4 | 64.5 ± 9.4 | 128.1 ± 7.0 |
NA = organ masses were not available for these calculations.
Absorbed radiation dose was calculated and is presented as mean ± SD. Model 1 assumes complete local β-ray absorption: Bladder absorbed dose was calculated without using dynamic bladder model. For walled organs (bladder, large intestine, small intestine, stomach), absorbed dose was calculated based on cpm of organs containing their respective contents. Model 2 uses spheric organ mass assumption: For 131I, there was nearly complete local absorption of β-radiation and correction was not necessary.