Biodistribution Data and T/NT Tissue Ratios in M109 Tumor-Bearing BALB/c Mice Injected with 99mTc-EC20 With or Without Free Folic Acid
| Organ | 99mTc-EC20 | 99mTc-EC20 + 1 eq. FA | 99mTc-EC20 + 10 eq. FA | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Codose | Predose | Codose | Predose | ||||||||||||||
| %ID/g | T/NT | %ID/g | T/NT | %ID/g | T/NT | %ID/g | T/NT | %ID/g | T/NT | ||||||||
| Blood | 0.32±0.11 | 79.6±15 | 0.08±0.01 | 213.6±87 | 0.12±0.06 | 148.0±39 | 0.05±0.01 | 98.2±17 | 0.05±0.02 | 111.3±63 | |||||||
| Heart | 1.89±0.41 | 13.4±3.5 | 0.72±0.09 | 23.0±5.7 | 0.90±0.40 | 20.2±7.8 | 0.29±0.02 | 16.3±2.7 | 0.26±0.05 | 19.4±2.7 | |||||||
| Lung | 2.00±0.54 | 13.2±5.7 | 0.67±0.04 | 24.8±7.5 | 0.73±0.14 | 22.7±1.3 | 0.23±0.03 | 20.5±6.5 | 0.27±0.02 | 18.6±3.8 | |||||||
| Liver | 4.70±1.01 | 5.3±0.7 | 1.84±0.39 | 9.3±3.3 | 2.86±0.20 | 5.7±0.6 | 1.63±0.18 | 2.9±0.4 | 1.92±0.57 | 2.8±1.3 | |||||||
| Spleen | 0.56±0.07 | 44.7±12 | 0.24±0.01 | 70.0±18.1 | 0.40±0.11 | 43.5±15.3 | 0.28±0.03 | 17.0±4.2 | 0.41±0.09 | 12.9±4.9 | |||||||
| Intestine | 3.91±1.34 | 6.6±1.8 | 1.12±0.45 | 17.9±12.4 | 2.03±1.34 | 11.4±7.8 | 1.88±0.28 | 2.6±0.9 | 1.34±1.18 | 7.5±7.7 | |||||||
| Kidney | 175.2±15 | 0.1±0.03 | 100.9±16 | 0.2±0.1 | 132.7±20 | 0.1±0.03 | 41.93±6.2 | 0.1±0.01 | 54.30±1.8 | 0.1±0.01 | |||||||
| Muscle | 1.80±0.21 | 13.6±2.0 | 0.48±0.13 | 36.7±15.9 | 0.82±0.16 | 20.3±4.2 | 0.18±0.05 | 26.5±3.3 | 0.30±0.06 | 17.3±4.3 | |||||||
| Stomach | 1.45±0.37 | 18.5±9.6 | 0.55±0.12 | 30.0±2.1 | 0.56±0.26 | 35.7±22.0 | 0.26±0.03 | 18.1±3.4 | 0.36±0.08 | 14.3±3.2 | |||||||
| Tumor | 24.66±5.9 | — | 16.51±4.6 | — | 16.47±2.7 | — | 4.65±0.85 | — | 5.00±0.72 | — | |||||||
FA = folic acid.
Values are means ± SD (n = 3).