Biodistribution of 99mTc-EC20
| Organ | Subcutaneous tumor | Intraperitoneal tumor* | ||||
|---|---|---|---|---|---|---|
| Intravenous dose | Intraperitoneal dose | Intravenous dose | Intraperitoneal dose | |||
| Blood | 0.26 ± 0.07 | 0.28 ± 0.06 | 0.38 ± 0.23 | 0.18 ± 0.02 | ||
| Heart | 2.20 ± 0.06 | 2.62 ± 0.50 | 1.34 ± 0.35 | 1.75 ± 0.42 | ||
| Lung | 1.58 ± 0.19 | 2.25 ± 0.37 | 1.46 ± 1.14 | 1.20 ± 0.13 | ||
| Liver | 4.22 ± 0.04 | 4.29 ± 0.71 | 4.67 ± 1.42 | 3.19 ± 0.15 | ||
| Intestine | 3.04 ± 2.04 | 2.64 ± 1.26 | 3.10 ± 2.24 | 2.77 ± 1.66 | ||
| Kidney | 109.90 ± 12.8 | 98.78 ± 6.9 | 125.96 ± 15.5 | 105.65 ± 11.1 | ||
| Muscle | 1.99 ± 0.39 | 1.90 ± 0.32 | 1.79 ± 0.80 | 1.39 ± 0.57 | ||
| Spleen | 0.44 ± 0.07 | 0.51 ± 0.13 | 1.81 ± 1.76 | 0.69 ± 0.15 | ||
| Tumor | 17.24 ± 4.22 | 18.77 ± 5.12 | 17.07 ± 3.39 | 16.24 ± 1.32 | ||
| Stomach | 1.43 ± 0.07 | 1.48 ± 0.12 | 1.49 ± 1.46 | 1.83 ± 0.88 | ||
↵* Each intraperitoneal tumor is sum of 4–6 tumor nodules (30–60 mg each).
BALB/c mice (weight, 20 ± 2 g) bearing subcutaneous or intraperitoneal tumors were injected intravenously or intraperitoneally with 99mTc-EC20 and then necropsied after 4 h. Values are the means ± SD (n = 3).