Dependency of 99mTc-EC20 Tumor Uptake on FR Density
| Cell line | FR expression* (pmol/mg protein) | 99mTc-EC20 uptake (%ID/g tissue) | ||||
|---|---|---|---|---|---|---|
| Cells | Tumors | EC20 | EC20 + 100 × FA | |||
| 4T1 | 1.6 | 1.5 | 2.58 ± 0.68 | 0.30 ± 0.05 | ||
| 4T1-pico | 20.2 | 7.2 | 8.71 ± 2.25 | 0.50 ± 0.05 | ||
| M109 | 95.5 | 22.9 | 15.53 ± 1.90 | 0.61 ± 0.05 | ||
↵* N = 1; however, typical errors for such measurements are <10%.
FA = folic acid.
Values are means ± SD (n = 3).