Biodistribution of 99mTc-EC20 and 99mTc-EC53
| Organ | 99mTc-EC20 | 99mTc-EC53 | ||||
|---|---|---|---|---|---|---|
| %ID/g | T/NT | %ID/g | T/NT | |||
| Blood | 0.27 ± 0.05 | 67.2 ± 5.6 | 0.38 ± 0.03 | 31.4 ± 13.7 | ||
| Heart | 1.97 ± 0.28 | 9.1 ± 0.9 | 1.09 ± 0.28 | 12.2 ± 8.2 | ||
| Lung | 2.39 ± 0.56 | 7.6 ± 1.3 | 0.89 ± 0.30 | 15.3 ± 10.4 | ||
| Liver | 3.48 ± 0.96 | 5.2 ± 0.8 | 3.86 ± 0.96 | 3.4 ± 2.2 | ||
| Intestine | 4.89 ± 1.37 | 3.7 ± 0.6 | 3.53 ± 0.86 | 3.6 ± 2.0 | ||
| Kidney | 116.46 ± 14.17 | 0.2 ± 0.01 | 77.99 ± 6.19 | 0.2 ± 0.1 | ||
| Muscle | 1.70 ± 0.70 | 11.3 ± 3.8 | 0.76 ± 0.31 | 17.1 ± 7.0 | ||
| Spleen | 0.46 ± 0.11 | 39.5 ± 7.5 | 0.67 ± 0.22 | 17.7 ± 2.4 | ||
| Tumor | 17.68 ± 1.95 | — | 11.77 ± 4.26 | — | ||
| Stomach | 1.47 ± 0.08 | 12.1 ± 0.8 | 1.04 ± 0.36 | 12.6 ± 7.3 | ||
Imaging agents were injected intravenously into BALB/c mice on folate-deficient diet bearing subcutaneous M109 tumors, and animals were necropsied 4 h later. Values are means ± SD (n = 3).