Regional Peak Uptake Times and Regional Activity Washout Rate
| Region | Subregion | 11C-DASB | 11C-McN 5652 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Peak uptake (min) | Washout* (%) | Peak specific (min) | Peak uptake (min) | Washout* (%) | Peak specific (min) | ||||||
| Cerebellum | 29.3 ± 8.5 | 60.7 ± 17.0 | — | 41.6 ± 15.1 | 28.4 ± 16.0 | — | |||||
| Midbrain | 71.3 ± 18.6 | 16.7 ± 15.2 | 70.1 ± 16.5 | 105.6 ± 20.7 | 1.8 ± 3.8 | 99.8 ± 21.6 | |||||
| Thalamus | 46.3 ± 10.7 | 38.7 ± 19.5 | 48.5 ± 11.7 | 66.5 ± 18.2 | 10.9 ± 11.8 | 75.0 ± 28.8 | |||||
| Striatal region | Caudate | 43.8 ± 9.8 | 42.0 ± 18.1 | 69.0 ± 17.7 | 67.7 ± 17.8 | 10.7 ± 12.3 | 69.0 ± 17.7 | ||||
| Putamen | 46.0 ± 10.7 | 38.9 ± 18.6 | 68.5 ± 17.3 | 69.0 ± 19.3 | 9.9 ± 11.0 | 68.5 ± 17.3 | |||||
| Ventral striatum | 51.7 ± 14.5 | 33.1 ± 19.7 | 51.0 ± 14.3 | 77.3 ± 17.1 | 6.1 ± 8.0 | 75.8 ± 13.0 | |||||
| Limbic region | Amygdala | 59.2 ± 16.1 | 24.5 ± 16.3 | 64.6 ± 17.5 | 88.3 ± 22.6 | 3.9 ± 5.9 | 86.9 ± 22.2 | ||||
| Entorhinal Ctx | 46.0 ± 11.6 | 39.4 ± 19.0 | 45.6 ± 11.3 | 69.6 ± 16.9 | 8.7 ± 8.4 | 70.8 ± 18.4 | |||||
| Parahippocampal gyrus | 39.6 ± 8.7 | 47.6 ± 17.7 | 39.6 ± 9.0 | 59.6 ± 14.9 | 14.2 ± 11.2 | 62.9 ± 17.6 | |||||
| Hippocampus | 42.5 ± 8.8 | 43.8 ± 18.3 | 41.9 ± 9.2 | 63.1 ± 16.5 | 12.4 ± 10.7 | 62.7 ± 15.7 | |||||
| Anterior cingulate | 35.2 ± 8.6 | 53.3 ± 19.1 | 35.2 ± 8.4 | 51.9 ± 15.7 | 20.1 ± 13.5 | 52.7 ± 17.1 | |||||
| Neocortical region | DLPFC | 29.4 ± 6.9 | 63.1 ± 16.8 | 25.0 ± 14.1 | 41.0 ± 12.3 | 29.2 ± 14.1 | 44.3 ± 17.2 | ||||
| MPFC | 30.2 ± 7.4 | 61.9 ± 17.4 | 30.0 ± 7.3 | 43.3 ± 12.2 | 27.1 ± 13.5 | 26.0 ± 22.6 | |||||
| OFC | 29.8 ± 9.1 | 62.5 ± 20.0 | 19.6 ± 16.8 | 41.0 ± 13.1 | 28.7 ± 13.4 | 17.1 ± 20.0 | |||||
| Temporal Ctx | 34.8 ± 8.2 | 53.8 ± 18.9 | 30.0 ± 16.6 | 51.3 ± 13.9 | 19.7 ± 12.2 | 31.5 ± 26.4 | |||||
| Parietal Ctx | 30.8 ± 6.3 | 61.6 ± 15.8 | 30.2 ± 6.3 | 43.1 ± 13.4 | 27.4 ± 14.9 | 30.8 ± 28.6 | |||||
| Occipital Ctx | 31.7 ± 7.0 | 58.2 ± 16.7 | 21.3 ± 17.8 | 45.0 ± 12.5 | 25.0 ± 12.7 | 27.1 ± 22.8 | |||||
↵* Regional activity washout rate (percentage decrease from peak to last frame, 120 min).
Ctx = cortex.
Values are mean ± SD of 6 experiments per tracer.