TABLE 2

Biodistribution and Specific Binding Ratio of 123I-ADAM in Rat Brain at 2 Hours After Injection of Radiotracer

Brain regionBiodistribution (%ID/mL)Specific binding ratio
High density
 Dorsal raphe nucleus1.28 ± 0.1216.48 ± 1.62
 Median raphe nucleus1.23 ± 0.2315.72 ± 3.18
 Interpeduncular nucleus1.04 ± 0.0213.20 ± 0.33
 Substantia nigra (reticular part)0.97 ± 0.0912.23 ± 1.27
 Medial forebrain bundle0.94 ± 0.1411.79 ± 1.94
 Nucleus raphe magnus0.84 ± 0.0710.47 ± 0.94
 Hypothalamus (lateral)0.84 ± 0.0610.39 ± 0.80
 Geniculate nucleus (ventral lateral)0.81 ± 0.0610.08 ± 0.79
 Globus pallidus0.76 ± 0.019.31 ± 0.19
 Amygdala (basolateral)0.72 ± 0.068.86 ± 0.86
 Thalamus (ventromedial)0.72 ± 0.088.76 ± 1.02
Moderate density
 Thalamus (mediodorsal)0.68 ± 0.018.31 ± 0.20
 Superior colliculus0.66 ± 0.048.04 ± 0.51
 Thalamus (laterodorsal)0.66 ± 0.088.03 ± 1.08
 Olfactory tubercle0.60 ± 0.057.18 ± 0.71
 Hypothalamus (dorsal)0.60 ± 0.097.12 ± 1.27
 Geniculate nucleus (dorsal lateral)0.57 ± 0.036.77 ± 0.35
 Amygdala (basomedial)0.55 ± 0.026.46 ± 0.22
 Amygdala (lateral)0.55 ± 0.046.44 ± 0.54
 Hippocampus0.51 ± 0.075.95 ± 0.91
Low density
 Cingulum0.46 ± 0.035.29 ± 0.39
 Hypothalamus (ventral)0.43 ± 0.044.82 ± 0.48
 Caudate putamen (dorsal)0.35 ± 0.013.74 ± 1.68
 Ventral pallidum0.33 ± 0.253.49 ± 3.40
 Lateral septal nucleus0.32 ± 0.173.30 ± 0.47
 Caudate putamen (ventral)0.29 ± 0.052.96 ± 2.35
 Prefrontal cortex0.25 ± 0.062.38 ± 0.85
 Cerebellum0.07 ± 0.00Reference