Biodistribution of 123I-ADAM in Mouse Brain Regions at 30 Minutes to 6 Hours After Intravenous Injection of Radiotracer
| Region | Biodistribution (%ID/mL) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 30 min | 60 min | 120 min | 240 min | 360 min | |||||
| Olf | 0.50 ± 0.09 | 0.43 ± 0.11 | 0.14 ± 0.03 | 0.05 ± 0.01 | 0.03 ± 0.01 | ||||
| GP | 0.54 ± 0.02 | 0.60 ± 0.11 | 0.33 ± 0.07 | 0.10 ± 0.01 | 0.03 ± 0.00 | ||||
| Cortex | 0.29 ± 0.01 | 0.20 ± 0.06 | 0.09 ± 0.02 | 0.04 ± 0.00 | 0.02 ± 0.00 | ||||
| HP | 0.47 ± 0.07 | 0.41 ± 0.07 | 0.15 ± 0.04 | 0.05 ± 0.00 | 0.03 ± 0.00 | ||||
| Th | 0.74 ± 0.10 | 0.70 ± 0.13 | 0.34 ± 0.07 | 0.09 ± 0.01 | 0.03 ± 0.00 | ||||
| HT | 0.63 ± 0.10 | 0.68 ± 0.11 | 0.33 ± 0.08 | 0.09 ± 0.01 | 0.03 ± 0.00 | ||||
| Am | 0.55 ± 0.08 | 0.59 ± 0.10 | 0.25 ± 0.06 | 0.07 ± 0.01 | 0.03 ± 0.00 | ||||
| SN | 0.88 ± 0.03 | 0.97 ± 0.18 | 0.58 ± 0.09 | 0.30 ± 0.03 | 0.11 ± 0.01 | ||||
| IP | 0.89 ± 0.02 | 0.79 ± 0.15 | 0.46 ± 0.09 | 0.15 ± 0.00 | 0.06 ± 0.00 | ||||
| DR | 0.91 ± 0.03 | 0.95 ± 0.14 | 0.61 ± 0.13 | 0.19 ± 0.02 | 0.08 ± 0.00 | ||||
| MR | 0.91 ± 0.07 | 0.85 ± 0.11 | 0.53 ± 0.10 | 0.21 ± 0.03 | 0.06 ± 0.01 | ||||
| ST | 0.44 ± 0.08 | 0.43 ± 0.11 | 0.14 ± 0.03 | 0.05 ± 0.00 | 0.02 ± 0.00 | ||||
| Cx | 0.27 ± 0.01 | 0.13 ± 0.02 | 0.07 ± 0.01 | 0.03 ± 0.00 | 0.02 ± 0.00 | ||||
Olf = olfactory bulb; GP = globus pallidus; HP = hippocampus; Th = thalamus; HT = hypothalamus; Am = amygdala; SN = substantia nigra; IP = interpeduncular nucleus; DR = dorsal raphe nucleus; MR = median raphe nucleus; ST = striatum; Cx = cerebellum.
Data are expressed as the average of 3 mice ± SD.