Target organ | Absorbed dose per unit administered activity (mGy/MBq) | Absorbed dose (Gy) | ||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
0.01 mg rhTSH | 0.03 mg rhTSH | 0.01 mg rhTSH | 0.03 mg rhTSH | |||||||||||||||||||
Treatment | Control | P | Treatment | Control | P | Treatment | Control | P | Treatment | Control | P | |||||||||||
Thyroid* | 92.60 ± 42.72 | 54.24 ± 19.59 | <0.05 | 139.40 ± 55.76 | 82.60 ± 48.84 | <0.05 | 113.41 ± 16.30 | 107.42 ± 12.69 | NS | 108.94 ± 15.52 | 109.75 ± 23.25 | NS | ||||||||||
Bone surface | 0.17 ± 0.02 | 0.11 ± 0.02 | <0.0001 | 0.18 ± 0.03 | 0.11 ± 0.01 | <0.0001 | 0.24 ± 0.09 | 0.25 ± 0.08 | NS | 0.15 ± 0.03 | 0.19 ± 0.10 | NS | ||||||||||
Breast | 0.06 ± 0.01 | 0.05 ± 0.01 | <0.05 | 0.07 ± 0.01 | 0.05 ± 0.00 | <0.0001 | 0.09 ± 0.04 | 0.11 ± 0.03 | NS | 0.06 ± 0.01 | 0.09 ± 0.04 | NS | ||||||||||
Colon† | 0.05 ± 0.01 | 0.06 ± 0.00 | <0.0001 | 0.07 ± 0.09 | 0.06 ± 0.00 | <0.005 | 0.07 ± 0.03 | 0.13 ± 0.04 | <0.005 | 0.06 ± 0.07 | 0.11 ± 0.06 | <0.05 | ||||||||||
Liver | 0.07 ± 0.02 | 0.05 ± 0.01 | <0.05 | 0.07 ± 0.01 | 0.05 ± 0.01 | <0.0001 | 0.10 ± 0.04 | 0.11 ± 0.03 | NS | 0.06 ± 0.02 | 0.08 ± 0.04 | NS | ||||||||||
Lungs | 0.13 ± 0.02 | 0.09 ± 0.01 | <0.001 | 0.15 ± 0.03 | 0.09 ± 0.01 | <0.0001 | 0.19 ± 0.07 | 0.21 ± 0.06 | NS | 0.12 ± 0.03 | 0.15 ± 0.08 | NS | ||||||||||
Ovaries | 0.05 ± 0.00 | 0.06 ± 0.00 | <0.0001 | 0.04 ± 0.01 | 0.06 ± 0.00 | <0.0001 | 0.06 ± 0.03 | 0.13 ± 0.04 | <0.01 | 0.04 ± 0.01 | 0.10 ± 0.05 | <0.01 | ||||||||||
Red bone marrow | 0.12 ± 0.02 | 0.09 ± 0.01 | <0.0001 | 0.13 ± 0.02 | 0.08 ± 0.01 | <0.0001 | 0.17 ± 0.07 | 0.19 ± 0.06 | NS | 0.11 ± 0.02 | 0.15 ± 0.08 | NS | ||||||||||
Skin | 0.12 ± 0.04 | 0.09 ± 0.02 | NS | 0.13 ± 0.04 | 0.08 ± 0.01 | <0.05 | 0.17 ± 0.07 | 0.20 ± 0.06 | NS | 0.11 ± 0.03 | 0.15 ± 0.08 | NS | ||||||||||
Stomach | 0.34 ± 0.03 | 0.45 ± 0.04 | <0.0001 | 0.31 ± 0.05 | 0.47 ± 0.02 | <0.0001 | 0.50 ± 0.24 | 0.99 ± 0.33 | <0.005 | 0.27 ± 0.09 | 0.81 ± 0.43 | <0.001 | ||||||||||
Testes | 0.02 ± 0.00 | 0.02 ± 0.00 | 0.05 ± 0.00 | 0.02 ± 0.00 | ||||||||||||||||||
Urinary bladder | 0.55 ± 0.08 | 0.71 ± 0.04 | <0.0001 | 0.51 ± 0.09 | 0.73 ± 0.03 | <0.0001 | 0.80 ± 0.37 | 1.55 ± 0.50 | <0.005 | 0.44 ± 0.16 | 1.27 ± 0.66 | <0.005 | ||||||||||
Remainder‡ | 0.10 ± 0.01 | 0.10 ± 0.00 | NS | 0.11 ± 0.02 | 0.09 ± 0.00 | <0.05 | 0.14 ± 0.06 | 0.21 ± 0.06 | <0.05 | 0.09 ± 0.02 | 0.17 ± 0.09 | NS | ||||||||||
EDE outside thyroid (Sv) | 0.21 ± 0.09 | 0.33 ± 0.10 | <0.05 | 0.12 ± 0.03 | 0.27 ± 0.14 | <0.05 |
↵* Thyroid absorbed doses as calculated with MIRDOSE3.1 are corrected for the ratio of normal thyroid weight (20 g) to measured actual thyroid weight determined by scintigraphy.
↵† 0.57 × dose to upper large intestine + 0.43 × dose to lower large intestine.
↵‡ The absorbed dose in the remainder of the body is the average dose in the following organs and tissues: adrenals, brain, upper large intestine, small intestine, kidney, muscle, pancreas, spleen, thymus, and uterus.
EDE = effective dose equivalent.
Data are mean ± SD (n = 9 patients in each group).