Patient Data
| Parameter | Value for patient: | Mean ± SD | Median | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P1 | P2 | P3 | P4 | P5 | P6 | ||||||||
| Patient age (y) | 57 | 37 | 46 | 32 | 45 | 32 | 42 ± 10 | 41 | |||||
| Patient height (cm) | 170 | 165 | 165 | 179 | 174 | 188 | 174 ± 9 | 172 | |||||
| Patient weight (kg) | 70 | 64 | 54 | 96 | 64 | 88 | 73 ± 16 | 67 | |||||
| BMI (kg/m2) | 24.2 | 23.5 | 19.8 | 30.0 | 21.1 | 24.9 | 23.9 ± 3.5 | 23.9 | |||||
| TNM stage (UICC 1997) | 3/0/0 | 2/0/0 | 4/0/0 | 2/0/0 | 2/0/0 | 2/0/0 | |||||||
| Time to THST (d) | 5 | 3 | 6 | 4 | 5 | NA | 4.6 ± 1.1 | 5.0 | |||||
| Time between surgery and first diagnostic course (d) | 92 | 95 | 67 | 68 | 105 | 36 | 77 ± 25 | 80 | |||||
| TSH baseline (mU/L) | 0.1 | 0.1 | 0.1 | 0.1 | 0.1 | 0.4 | |||||||
| rhTSH regimen (no. of doses) | 2 | 3 | 2 | 2 | 3 | 2 | |||||||
| TSH at first diagnostic course (mU/L) | >80 | >80 | >80 | >80 | >80 | >80 | |||||||
| Tg at first diagnostic course (ng/mL) | 1.8 | 4.0 | 1.1 | 0.4 | 4.4 | 3.5 | 2.5 ± 1.6 | 2.6 | |||||
| Time between first and second diagnostic courses (d) | 37 | 30 | 35 | 35 | 44 | 42 | 37 ± 5 | 36 | |||||
| TSH at second diagnostic course (mU/L) | 26 | >80 | >80 | >80 | >80 | >80 | |||||||
| Tg at second diagnostic course (ng/mL) | 3.4 | 16 | 2.7 | 0.4 | 3.7 | 0.5 | 4.5 ± 5.8 | 3.1 | |||||
| Time between second diagnostic course and therapy (d) | 9 | 7 | 7 | 8 | 7 | 12 | 8.3 ± 2.0 | 7.5 | |||||
| TSH at therapy (mU/L) | 42 | >80 | >80 | >80 | >80 | >80 | |||||||
| Tg at therapy (ng/mL) | 4.5 | 7.2 | 2.7 | 0.4 | 2.9 | 0.8 | 3.1 ± 2.5 | 2.8 | |||||
| Therapeutic activity (GBq) | 3.1 | 3.27 | 3.71 | 3.56 | 3.07 | 3.85 | 3.43 ± 0.33 | 3.42 | |||||
| Outcome (at 6 mo follow-up) | CR | 131I+ | CR | CR | CR | 131I+ | |||||||
BMI = body mass index; Tg = thyroglobulin; NA = not applicable; CR = complete remission (Tg level < 0.2 ng/mL; no evidence of pathologic 131I uptake in subsequent diagnostic scans; UICC 1997 = International Union Against Cancer, 5th edition); 131I+ = 131I-positive scan.