TABLE 1

Kinetic Parameters and Bmax in Isolated Rat Hearts

GroupDVtot (mL/g)kon/VR (g/min/pmol)koff (min−1)Bmax (pmol/g)KDVR (pmol/g)
High flow4.4 ± 1.60.094 ± 0.0240.23 ± 0.065.05 ± 0.902.56 ± 0.53
Low flow3.9 ± 1.10.060 ± 0.011*0.17 ± 0.065.20 ± 0.633.01 ± 0.94
β-blocker2.0 ± 0.3†————

  • ↵* P < 0.01 compared with kon/VR in high-flow group.

  • ↵† P < 0.01 compared with DVtot in high-flow and low-flow groups.