TABLE 4

Mean Binding Ratios and Sensitivity and Specificity of ^99mTc-TRODAT-1 of 23 PD Patients with H–Y Stage I and 26 Age-Matched Healthy Volunteers

Age group (y)	^99mTc-TRODAT-1 binding ratio (mean ± SD)
Age group (y)		C-S/O	I-S/O	C-C/O	I-C/O	C-P/O	I-P/O	C-P/C	I-P/C
50–59
Control (n = 12)	0.95 ± 0.08	0.95 ± 0.06	1.27 ± 0.08	1.26 ± 0.08	0.80 ± 0.05	0.81 ± 0.06	0.63 ± 0.04	0.64 ± 0.05
Hemi-PD (n = 8)	0.39 ± 0.12*	0.55 ± 0.20*	0.82 ± 0.28*	0.94 ± 0.32*	0.22 ± 0.13*	0.39 ± 0.16*	0.26 ± 0.12*	0.43 ± 0.14*
Cutoff†	0.725	0.832	1.143	1.230	0.542	0.669	0.485	0.540
Sensitivity‡ (%)	100	100	100	100	100	100	100	87.5
Specificity§ (%)	100	100	92.9	71.4	100	100	100	100
60–69
Control (n = 14)	0.86 ± 0.08	0.87 ± 0.09	1.18 ± 0.13	1.17 ± 0.15	0.73 ± 0.07	0.74 ± 0.07	0.62 ± 0.06	0.63 ± 0.06
Hemi-PD (n = 15)	0.28 ± 0.10*	0.38 ± 0.14*	0.65 ± 0.19*	0.73 ± 0.21*	0.14 ± 0.09*	0.25 ± 0.13*	0.28 ± 0.12*	0.40 ± 0.14*
Cutoff†	0.632	0.752	0.949	1.023	0.477	0.601	0.534	0.554
Sensitivity‡ (%)	100	100	92.3	84.6	100	100	100	100
Specificity§ (%)	100	100	100	92.9	100	100	100	100
Total
Control (n = 26)	0.90 ± 0.08	0.91 ± 0.14	1.22 ± 0.12	1.21 ± 0.12	0.77 ± 0.07	0.77 ± 0.07	0.63 ± 0.05	0.64 ± 0.05
Hemi-PD (n = 23)	0.39 ± 0.12*	0.54 ± 0.08*	0.81 ± 0.22*	0.94 ± 0.22*	0.23 ± 0.10*	0.38 ± 0.14*	0.28 ± 0.12*	0.41 ± 0.13*
Cutoff†	0.684	0.813	1.083	1.09	0.515	0.658	0.526	0.540
Sensitivity‡ (%)	100	92.9	89.9	66.7	100	100	100	94.4
Specificity§ (%)	100	100	89.3	89.3	100	100	100	100

↵* P < 0.0001.
↵^† Cutoff means binding ratios that have the maximal probability of correctly assigning patients and controls to their respective groups. All cutoff values are averages of 2 consecutively ordered, observed test values.
↵^‡ True-positive rate.
↵^§ One minus the false-positive rate.
Abbreviations are as defined in Table 2.