Binding Parameters of 11C-NPA in Baboons*
| Baboon | BP (mL/g) | V3″ (unitless) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Kinetic analysis | Graphical with arterial input | Kinetic analysis | Graphical with arterial input | Graphical with reference region input | SRTM analysis | |||||
| A | 4.78 ± 1.02 | 4.63 ± 0.98 | 1.29 ± 0.17 | 1.36 ± 0.17 | 1.35 ± 0.17 | 1.41 ± 0.18 | ||||
| B | 3.30 ± 0.67† | 3.17 ± 0.50† | 1.03 ± 0.12† | 1.09 ± 0.11† | 1.08 ± 0.11† | 1.13 ± 0.13† | ||||
| Mean | 4.04 ± 1.05 | 3.90 ± 1.03‡ | 1.16 ± 0.18 | 1.23 ± 0.19‡ | 1.22 ± 0.17‡ | 1.27 ± 0.19§ | ||||
↵* Values are mean ± SD; n = 4 per animal.
↵† Significantly different between the 2 baboons (unpaired t test; P < 0.05).
↵‡ Significantly different from values derived with kinetic analysis (paired t test; P < 0.05).
↵§ Significantly different from values derived with kinetic analysis (paired t test; P < 0.001).