TABLE 3

Fractional Rate Constants and Total Distribution Volumes of ¹¹C-NPA in Baboons*

Baboon	Cerebellum							Striatum
		Kinetic analysis					Graphical analysis with arterial input	Kinetic analysis		Graphical analysis with arterial input
		K₁ (mL/g/min)	k₂ (min)	V_T (mL/g)	(V_T [mL/g])	K₁ (mL/g/min)	k₂ (min)	V_T (mL/g)	(V_T [mL/g])
A	1.06 ± 0.21	0.29 ± 0.05	3.72 ± 0.53	3.39 ± 0.45	1.11 ± 0.28	0.13 ± 0.03	8.50 ± 1.51	8.02 ± 1.40
B	0.76 ± 0.11^†	0.24 ± 0.04	3.17 ± 0.31	2.90 ± 0.26	0.67 ± 0.13^†	0.10 ± 0.02	6.47 ± 0.97^†	6.07 ± 0.71^†
Mean	0.91 ± 0.21	0.27 ± 0.03	3.44 ± 0.39	3.15 ± 0.35^‡	0.89 ± 0.31	0.12 ± 0.02	7.48 ± 1.44	7.05 ± 1.38^‡

↵* Values are mean ± SD; n = 4 per animal.
↵^† Significantly different from baboon A (unpaired t test; P < 0.05).
↵^‡ Significantly different from values derived with kinetic analysis (paired t test; P < 0.01).