Comparison of 18F-Fluoride PET and PET/CT Results in Assessment of Metastatic Bone Disease
| Location | Final diagnosis | Statistical analysis* | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lesion total (n) | Metastases (n) | Benign findings (n) | Inconclusive findings (n) | PET | PET/CT | P | ||||||||||||
| Sens | Spec | Sens | Spec | Sens | Spec | |||||||||||||
| All | 212 | 111 | 89 | 12 | 72 (90) | 72 | 85 (99) | 97 | <0.05 | <0.001 | ||||||||
| Vertebral column | 98 | 38 | 58 | 2 | 50 (84) | 86 | 84 (97) | 100 | <0.001 | <0.05 | ||||||||
| Thoracic cage | 37 | 17 | 15 | 5 | 76 (100) | 40 | 94 (100) | 87 | NS | <0.05 | ||||||||
| Pelvic bones | 41 | 29 | 9 | 3 | 83 (97) | 67 | 86 (97) | 89 | NS | NS | ||||||||
| Skull and facial bones | 18 | 15 | 3 | 0 | 80 (100) | 30 | 60 (100) | 100 | NS | NS | ||||||||
| Long bones | 18 | 12 | 4 | 2 | 100 (100) | 25 | 100 | 100 | NS | NS | ||||||||
↵* 18F-Fluoride PET and PET/CT were compared using the McNemar test. P < 0.05 was considered statistically significant.
Sens = sensitivity; Spec = specificity; NS = not statistically significant.
A metastasis categorized as inconclusive on PET or PET/CT was considered false negative. The sensitivity in brackets is when considering the latter lesions as true positive for metastasis.