TABLE 3

Biodistribution of Radiolabeled cG250 Immunoconjugates*

Organ	Days after injection^†	Preparation
Organ	Days after injection^†			⁸⁸Y-cDTPA	⁸⁸Y-SCN-Bz-DTPA	⁸⁸Y-DOTA	¹⁷⁷Lu-cDTPA	¹⁷⁷Lu-SCN-Bz-DTPA	¹⁷⁷Lu-DOTA	¹²⁵I	¹⁸⁶Re-MAG3
Tumor	1	32.9 ± 7.2	34.8 ± 8.5	36.2 ± 14.1	34.6 ± 10.8	53.2 ± 21.1	41.3 ± 9.9	11.7 ± 1.5	13.5 ± 1.8
	3	46.6 ± 19.7	51.9 ± 7.0	44.4 ± 14.8	59.0 ± 11.5	113.3 ± 24.7	86.9 ± 14.5	14.0 ± 3.0	16.9 ± 2.8
	7	27.4 ± 4.8	70.9 ± 8.4	55.3 ± 10.7	45.0 ± 30.0	87.3 ± 14.0	74.5 ± 10.5	9.1 ± 2.0	7.9 ± 2.0
Muscle	1	0.8 ± 0.1	1.3 ± 0.4	1.3 ± 0.2	1.1 ± 0.3	1.4 ± 0.1	1.2 ± 0.2	1.4 ± 0.1	1.2 ± 0.4
	3	0.5 ± 0.1	1.2 ± 0.2	1.4 ± 0.2	0.6 ± 0.2	1.1 ± 0.2	1.1 ± 0.1	1.0 ± 0.1	1.1 ± 0.3
	7	0.2 ± 0.1	0.9 ± 0.3	0.7 ± 0.2	0.3 ± 0.1	0.6 ± 0.2	0.6 ± 0.1	0.6 ± 0.2	0.5 ± 0.2
Blood	1	12.8 ± 0.9	16.4 ± 2.3	15.2 ± 3.2	16.5 ± 1.4	21.0 ± 1.4	14.9 ± 1.2	16.9 ± 0.9	17.3 ± 1.4
	3	5.9 ± 0.8	11.8 ± 2.9	12.5 ± 1.3	6.7 ± 0.5	13.4 ± 3.8	11.3 ± 1.2	12.4 ± 1.3	14.8 ± 1.5
	7	1.5 ± 0.2	8.4 ± 1.8	8.2 ± 1.9	1.6 ± 1.0	5.9 ± 1.7	6.0 ± 1.6	6.8 ± 1.6	6.7 ± 1.0
Femur	1	6.3 ± 1.1	1.1 ± 0.5	0.7 ± 0.2	5.2 ± 1.2	1.3 ± 0.3	0.6 ± 0.2	0.7 ± 0.1	0.5 ± 0.2
	3	10.7 ± 1.3	1.3 ± 0.6	1.0 ± 0.2	11.0 ± 2.7	1.3 ± 0.3	0.2 ± 0.1	0.5 ± 0.0	0.4 ± 0.1
	7	10.7 ± 2.4	1.2 ± 0.2	0.4 ± 0.3	14.2 ± 4.7	1.5 ± 0.3	0.3 ± 0.2	0.4 ± 0.2	0.2 ± 0.1
Spleen	1	3.7 ± 0.6	3.4 ± 0.6	2.7 ± 0.4	5.2 ± 2.0	5.5 ± 0.9	3.4 ± 0.5	2.9 ± 0.2	2.7 ± 0.4
	3	3.4 ± 0.9	2.9 ± 0.6	2.8 ± 0.3	4.2 ± 0.8	6.3 ± 1.5	3.2 ± 0.5	2.1 ± 0.4	2.6 ± 0.4
	7	2.5 ± 0.5	3.0 ± 0.4	2.4 ± 0.3	4.8 ± 2.1	6.6 ± 2.1	2.9 ± 0.2	1.2 ± 0.3	1.0 ± 0.1
Kidney	1	7.1 ± 0.6	4.8 ± 0.6	4.8 ± 0.8	7.7 ± 0.5	6.7 ± 0.5	4.7 ± 0.4	4.4 ± 0.3	4.5 ± 0.2
	3	5.8 ± 0.7	3.9 ± 0.7	4.5 ± 0.5	6.1 ± 0.9	4.1 ± 1.3	3.8 ± 0.4	3.2 ± 0.3	3.6 ± 0.3
	7	3.9 ± 0.8	2.6 ± 0.4	2.7 ± 0.6	3.7 ± 0.9	2.4 ± 0.3	2.2 ± 0.4	1.8 ± 0.5	1.7 ± 0.3
Liver	1	6.5 ± 0.7	5.8 ± 0.9	5.7 ± 0.6	9.0 ± 0.5	10.4 ± 3.2	4.5 ± 0.4	3.7 ± 0.1	4.8 ± 0.5
	3	5.3 ± 0.2	5.9 ± 0.3	7.0 ± 0.7	10.1 ± 3.1	16.6 ± 5.6	4.2 ± 0.4	2.8 ± 0.1	3.5 ± 0.4
	7	4.9 ± 1.2	4.2 ± 0.6	3.7 ± 0.4	8.6 ± 2.1	16.7 ± 2.1	4.0 ± 0.6	1.7 ± 0.5	1.6 ± 0.4
Intestine	1	3.7 ± 1.1	2.5 ± 0.4	2.4 ± 0.6	3.4 ± 1.0	3.8 ± 1.1	2.4 ± 0.8	3.5 ± 0.6	3.2 ± 0.7
	3	2.3 ± 0.8	1.8 ± 0.4	2.1 ± 0.4	2.2 ± 0.4	2.8 ± 0.8	1.9 ± 0.5	2.8 ± 0.5	2.5 ± 0.6
	7	0.8 ± 0.2	1.4 ± 0.3	1.7 ± 0.3	1.2 ± 0.3	1.5 ± 0.3	1.4 ± 0.4	1.3 ± 0.3	1.2 ± 0.3

↵* Values given as %ID/g tissue ± SD.
↵^† Protein doses in the radiolabeled preparations were 50 μg each for ⁸⁸Y-cDTPA, ⁸⁸Y-DOTA, ⁸⁸Y-SCN-Bz-DTPA, and ¹⁸⁶Re-MAG3; 30 μg each for ¹⁷⁷Lu-cDTPA, ¹⁷⁷Lu-SCN-Bz-DTPA, and ¹⁷⁷Lu-DOTA; and 16 μg for ¹²⁵I.