TABLE 2

Immunohistochemical Data According to Age at Surgery

ParameterMarkerAge categoryMedianRangeP
% Stained thyrocytes*NIS≤12 y old31–4<0.01
>12 y old11–3
Pendrin≤12 y old32–4<0.01
>12 y old22–3
AIT≤12 y old11–2NS
>12 y old11–2
TPO≤12 y old33–3NS
>12 y old32–4
Duox≤12 y old32–3<0.01
>12 y old22–3
VEGF≤12 y old33–4NS
>12 y old33–4
NOSIII≤12 y old11–2NS
>12 y old11–2
Intensity of staining†NIS≤12 y old33–3NS
>12 y old33–3
Pendrin≤12 y old33–3NS
>12 y old33–3
AIT≤12 y old22–2NS
>12 y old22–2
TPO≤12 y old21–3NS
>12 y old21–3
Duox≤12 y old21–3<0.05
>12 y old11–2
VEGF≤12 y old11–1NS
>12 y old11–1
NOSIII≤12 y old11–2NS
>12 y old11–1

  • ↵* 0 = no cells; 1 = <25%; 2 = 25%–50%; 3 = 50%–75%; 4 = >75%.

  • ↵† 0 = absent; 1 = weak; 2 = moderate; 3 = strong.

    NS = not significant.