Circulating and Tissue RAS Components During Both Phases of Study, as Measured In Vivo and In Vitro
| Phase | Parameter | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| E2 (pg/mL) | PRA (ng/ mL/h) | Aldosterone (pg/mL) | AT1R in vivo (Ki) | AT1R Bmax in vitro (fmol/mg protein) | |||||||||||||
| Renal | Adrenal | Glomerular | Adrenal | Liver | Myocardial | ||||||||||||
| Off estrogen | ND | 1.37 ± 0.54 | 26 ± 11 | 0.022 ± 0.006 | 0.036 ± 0.011 | 1,243 ± 56 | 253.4 ± 20 | 70.7 ± 3 | 16.8 ± 1 | ||||||||
| On estrogen | 317.9 ± 96* | 1.85 ± 0.5* | ND* | 0.017 ± 0.005* | 0.025 ± 0.007* | 873.3 ± 42* | 165.9 ± 12* | 55.9 ± 3* | 11.1 ± 2 | ||||||||
↵* P < 0.05.
AT1R = AT1 receptor; ND = not detectable.
Data are expressed as mean ± SEM.