Biodistribution of 67Ga- and 111In-IMP 241 at Times Indicated After Injection, When Administered 15 Hours After Bispecific Construct BS1.5H
| Ratio | Time after injection of peptide (+ 15 h after injection of bsAb) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| 67Ga | 111In | ||||||||
| 1 h | 3 h | 24 h | 3 h | 24 h | |||||
| Liver | 51 ± 14 | 106 ± 27 | 87 ± 17 | 120 ± 36 | 101 ± 33 | ||||
| Spleen | 495 ± 501 | 177 ± 32 | 117 ± 11 | 181 ± 58 | 126 ± 42 | ||||
| Kidney | 1.4 ± 0.3 | 2.3 ± 0.5 | 2.6 ± 0.6 | 3.0 ± 1.1 | 3.3 ± 1.2 | ||||
| Lungs | 16 ± 2 | 46 ± 9 | 89 ± 16 | 49 ± 19 | 113 ± 34 | ||||
| Blood | 41 ± 12 | 137 ± 23 | 189 ± 42 | 284 ± 51 | 653 ± 207 | ||||
| Stomach | 183 ± 101 | 389 ± 136 | 336 ± 67 | 530 ± 292 | 481 ± 330 | ||||
| Small intestine | 39 ± 11 | 212 ± 54 | 127 ± 22 | 235 ± 139 | 195 ± 98 | ||||
| Large intestine | 104 ± 47 | 69 ± 14 | 102 ± 50 | 62 ± 33 | 102 ± 55 | ||||
Data are expressed as tumor-to-tissue ratios ± SD (5 animals per group).