Biodistribution | Time after cyclophosphamide treatment (h) (n = 5) | P (K–W) | ||||||
---|---|---|---|---|---|---|---|---|
0 (control) | 4 | 12 | 20 | |||||
Blood | 0.039 ± 0.006 | 0.041 ± 0.005 | 0.041 ± 0.007 | 0.037 ± 0.001 | NS | |||
Tumor | 0.050 ± 0.010 | 0.048 ± 0.008 | 0.052 ± 0.014 | 0.077 ± 0.007* | <0.001 | |||
Muscle | 0.008 ± 0.001 | 0.011 ± 0.008 | 0.009 ± 0.002 | 0.010 ± 0.000 | NS | |||
Thymus | 0.031 ± 0.004 | 0.041 ± 0.007 | 0.065 ± 0.012* | 0.068 ± 0.011* | <0.001 | |||
Spleen | 1.321 ± 0.183 | 2.111 ± 0.432* | 2.410 ± 0.463* | 2.355 ± 0.157* | 0.001 | |||
BM | 0.621 ± 0.048 | 1.237 ± 0.193* | 1.493 ± 0.429* | 2.048 ± 0.521* | <0.001 | |||
Liver | 0.586 ± 0.042 | 0.740 ± 0.111 | 0.743 ± 0.204 | 0.669 ± 0.087 | NS | |||
Kidney | 8.317 ± 0.295 | 6.897 ± 0.968 | 5.958 ± 1.452* | 5.945 ± 0.583* | 0.002 | |||
TBR | 1.306 ± 0.217 | 1.197 ± 0.288 | 1.281 ± 0.312 | 2.052 ± 0.164* | <0.001 | |||
TMR | 5.908 ± 0.839 | 5.873 ± 2.692 | 5.733 ± 1.690 | 7.528 ± 0.586* | <0.001 |
↵* P < 0.05 compared with control groups.
K-W = Kruskal-Wallis test; NS = not significant; BM = bone marrow; TBR = tumor-to-blood ratio; TMR = tumor-to-muscle ratio.
Data are (%ID/g) × kg (mean ± SD) except TBR and TMR.