Tissue Distribution of Peptide Mismatch Probe, WT4113, After Systemic Administration (n = 5)
| Tissue | Tissue distribution (mean ± SD %ID/g) of WT4113 at the following hours after administration: | ||||
|---|---|---|---|---|---|
| 4 | 12 | 24 | |||
| Muscle | 0.33 ± 0.06 | 0.13 ± 0.02 | 0.13 ± 0.03 | ||
| Intestine | 0.39 ± 0.06 | 0.14 ± 0.00 | 0.16 ± 0.04 | ||
| Heart | 0.35 ± 0.02 | 0.29 ± 0.04 | 0.19 ± 0.05 | ||
| Lung | 0.63 ± 0.05 | 0.42 ± 0.08 | 0.31 ± 0.06 | ||
| Blood | 0.61 ± 0.04 | 0.40 ± 0.07 | 0.17 ± 0.03 | ||
| Spleen | 0.40 ± 0.04 | 0.53 ± 0.22 | 1.28 ± 0.53 | ||
| Kidney | 10.30 ± 1.07 | 4.22 ± 0.67 | 5.51 ± 1.15 | ||
| Liver | 2.00 ± 0.21 | 1.56 ± 0.25 | 2.74 ± 0.75 | ||
| Tumor | 0.53 ± 0.07 | 0.28 ± 0.04 | 0.20 ± 0.06 | ||
| T/M ratio | 1.64 ± 0.29 | 2.25 ± 0.69 | 1.74 ± 0.88 | ||
| T/B ratio | 0.88 ± 0.14 | 0.72 ± 0.22 | 1.23 ± 0.47 | ||
T/M ratio = tumor distribution-to-muscle distribution ratio; T/B ratio = tumor distribution-to-blood distribution ratio.