Tissue Distribution of PNA-Free Probe, WT990, After Systemic Administration (n = 5)
| Tissue | Tissue distribution (mean ± SD %ID/g) of WT990 at the following hours after administration: | ||||
|---|---|---|---|---|---|
| 4 | 12 | 24 | |||
| Muscle | 0.14 ± 0.10 | 0.04 ± 0.01 | 0.08 ± 0.02 | ||
| Intestine | 0.09 ± 0.01 | 0.15 ± 0.19 | 0.06 ± 0.02 | ||
| Heart | 0.05 ± 0.01 | 0.05 ± 0.00 | 0.07 ± 0.01 | ||
| Lung | 0.16 ± 0.01 | 0.12 ± 0.02 | 0.14 ± 0.02 | ||
| Blood | 0.11 ± 0.01 | 0.07 ± 0.01 | 0.08 ± 0.00 | ||
| Spleen | 0.08 ± 0.01 | 0.13 ± 0.05 | 0.41 ± 0.16 | ||
| Kidney | 7.82 ± 1.21 | 4.78 ± 0.54 | 2.10 ± 0.28 | ||
| Liver | 0.36 ± 0.03 | 0.41 ± 0.09 | 0.77 ± 0.22 | ||
| Tumor | 0.16 ± 0.08 | 0.09 ± 0.03 | 0.09 ± 0.01 | ||
| T/M ratio | 1.31 ± 0.32 | 2.85 ± 1.48 | 1.06 ± 0.10 | ||
| T/B ratio | 1.43 ± 0.76 | 1.35 ± 0.42 | 1.10 ± 0.17 | ||
T/M ratio = tumor distribution-to-muscle distribution ratio; T/B ratio = tumor distribution-to-blood distribution ratio.