Dosimetry of Single Dose of 225Ac-HuM195 Following Pharmacokinetics in Monkey 2
| Isotope | No. of disintegrations (/37 kBq) | Absorbed dose (Gy/37 kBq) | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Blood (Bq-s/kg) | RC (Bq-s) | Blood | RC | |||||||||||
| A | B | A | B | A | B | A | B | |||||||
| 225Ac | 1.5 × 1010 | 1.5 × 1010 | 0 | 0 | 0.014 | 0.014 | 0 | 0 | ||||||
| 221Fr | 1.5 × 1010 | 8.1 × 109 | 0 | 3.2 × 109 | 0.016 | 0.008 | 0 | 0.05 | ||||||
| 217At | 1.5 × 1010 | 8.1 × 109 | 0 | 3.2 × 109 | 0.017 | 0.009 | 0 | 0.06 | ||||||
| 213Bi | 8.1 × 109 | 8.1 × 109 | 3.2 × 109 | 3.2 × 109 | 0.011 | 0.011 | 0.07 | 0.07 | ||||||
| Total | 5.4 × 1010 | 4.0 × 1010 | 3.2 × 109 | 9.6 × 109 | 0.058 | 0.042 | 0.07 | 0.17 | ||||||
RC = renal cortex portion of kidney.
A and B refer to radionuclide decay assumptions A and B in text.