Biodistribution of 18F-FE-SA5845 in Tumor-Bearing Rats 60 Minutes After Injection
| Tissue | Control (n = 5) | Haloperidol (n = 5) | P |
|---|---|---|---|
| Cerebellum | 1.41 ± 0.23 | 0.43 ± 0.12 | <0.0001 |
| Cerebral cortex | 1.26 ± 0.31 | 0.45 ± 0.16 | 0.0005 |
| Rest brain | 1.42 ± 0.28 | 0.41 ± 0.13 | 0.0001 |
| Adipose tissue | 0.46 ± 0.18 | 0.45 ± 0.26 | NS |
| Bladder | 1.61 ± 0.94 | 0.95 ± 0.45 | NS |
| Bone | 0.42 ± 0.14 | 0.39 ± 0.13 | NS |
| Heart | 0.47 ± 0.16 | 0.66 ± 0.25 | NS |
| Large intestine | 1.76 ± 0.18 | 0.84 ± 0.30 | 0.0002 |
| Small intestine | 2.35 ± 0.44 | 1.13 ± 0.35 | 0.0006 |
| Kidney | 4.95 ± 0.84 | 1.77 ± 0.58 | <0.0001 |
| Liver | 9.28 ± 1.50 | 5.58 ± 2.24 | <0.01 |
| Lung | 2.93 ± 0.83 | 2.50 ± 1.09 | NS |
| Muscle | 0.20 ± 0.07 | 0.25 ± 0.10 | NS |
| Pancreas | 4.23 ± 0.85 | 4.39 ± 2.69 | NS |
| Plasma | 0.12 ± 0.03 | 0.23 ± 0.05 | <0.001 |
| Red blood cells | 0.08 ± 0.01 | 0.16 ± 0.05 | <0.05 |
| Spleen | 2.05 ± 0.46 | 1.43 ± 0.53 | 0.08 |
| Submandibular | 2.33 ± 0.85 | 1.31 ± 0.73 | 0.06 |
| C6 tumor* | 0.92 ± 0.39 | 0.37 ± 0.18 | 0.0005 |
| Urine | 9.71 ± 6.54 | 9.45 ± 3.88 | NS |
| Tumor/plasma* | 8.0 ± 3.2 | 1.4 ± 0.9 | <0.0001 |
| Tumor/muscle* | 4.9 ± 2.8 | 1.5 ± 0.9 | 0.001 |
↵* Twice as much data (2 n) since each rat had 2 tumors.
NS = not significant.
SUVs (and dimensionless ratios) are listed (mean ± SD).