Treatment* | Apoptosis index† | Tumor uptake (%ID/g)‡ |
---|---|---|
Control | 1.67 ± 0.31 | 6.14 ± 0.67 |
Poly(l-glutamic acid)-paclitaxel (1 d) | 4.33 ± 0.31§ | 6.95 ± 1.11 |
Poly(l-glutamic acid)-paclitaxel (4 d) | 7.60 ± 0.72§ | 10.76 ± 1.38§ |
C225 (1 d) | 2.73 ± 0.46¶ | 6.99 ± 1.49 |
C225 (4 d) | 1.93 ± 0.50 | 4.69 ± 0.54¶ |
Poly(l-glutamic acid)-paclitaxel/C225 (4 d) | 11.07 ± 1.81§ | 9.84 ± 2.51¶ |
↵* Poly(l-glutamic acid)-paclitaxel was given intravenously at dose of 100 mg eq paclitaxel/kg; C225 was given intraperitoneally at dose of 1 mg per mouse per injection.
↵† Apoptosis index for cancer cells is expressed as mean percentage ± SD of values from 3 mice. For each mouse, apoptosis index was determined from average of percentage of apoptotic nuclei within 5 randomly selected ×400 fields.
↵‡ %ID/g of tumor. Data are presented as mean percentage ± SD of values from 3 mice.
↵§ P < 0.001 vs. control (Student t test).
↵¶ P < 0.05 vs. control (Student t test).
Data were obtained 48 h after radiotracer injection.