Schematic Overview of Animal Experiments
Rabbit no. | Days | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
−4 | −3 | −2 | −1 | 0 | 1 | ||||||
1–5: group A | Blood Cytarabine | Induction Aspergillosis + cytarabine | Cytarabine | Cytarabine | Blood 111In-DPC11870 + imaging | Imaging + biodistribution | |||||
6–10: group B | Blood Cytarabine | Induction Aspergillosis + cytarabine | Cytarabine | Cytarabine | Blood 67Ga-Citrate + imaging | Imaging + biodistribution | |||||
11–12: group C | Blood Cytarabine | Cytarabine | Cytarabine | Cytarabine | Blood 111In-DPC11870 + imaging | Imaging + biodistribution | |||||
13–14: group D | Blood | Blood 111In-DPC11870 + imaging | Imaging + biodistribution |
Blood samples were taken on day −4 and 0 to determine WBC count. Animals were injected with cytarabine on days −4 through 0, and aspergillosis was induced on day −3. At day 0, animals were injected with 111In-DPC11870 (groups A, C, and D) or 67Ga-citrate. Animals of group C were not inoculated with aspergillosis, and animals from group D were not injected with aspergillosis or cytarabine.