TABLE 1

Schematic Overview of Animal Experiments

Rabbit no.Days
−4−3−2−101
1–5: group ABlood CytarabineInduction Aspergillosis + cytarabineCytarabineCytarabineBlood 111In-DPC11870 + imagingImaging + biodistribution
6–10: group BBlood CytarabineInduction Aspergillosis + cytarabineCytarabineCytarabineBlood 67Ga-Citrate + imagingImaging + biodistribution
11–12: group CBlood CytarabineCytarabineCytarabineCytarabineBlood 111In-DPC11870 + imagingImaging + biodistribution
13–14: group DBloodBlood 111In-DPC11870 + imagingImaging + biodistribution
  • Blood samples were taken on day −4 and 0 to determine WBC count. Animals were injected with cytarabine on days −4 through 0, and aspergillosis was induced on day −3. At day 0, animals were injected with 111In-DPC11870 (groups A, C, and D) or 67Ga-citrate. Animals of group C were not inoculated with aspergillosis, and animals from group D were not injected with aspergillosis or cytarabine.