TABLE 3

Calculated Radioiodinated Fractions of Antibodies for Different Numbers of Iodine Atoms per mAb Molecule

No. of iodine atoms	Iodination probability* (P_i(x))	Relative iodination probability^† (%)	Radiolabeling probability^‡ (P_a(x))	Radioiodinated fraction^§ (F(x))	Relative radioiodinated fraction^‖ (%)
Labeling A
1	0.3645	62.7	0.0455	0.01658	42.7
2	0.1586	27.3	0.0888	0.01408	36.3
3	0.0460	7.9	0.1303	0.00599	15.5
4	0.0100	1.7	0.1698	0.00170	4.4
5	0.0017	0.3	0.2075	0.00035	0.9
6	0.0003	0.1	0.2436	0.00007	0.2
Labeling B
1	0.1413	91.6	0.0455	0.00643	84.6
2	0.0122	7.9	0.0888	0.00108	14.2
3	0.0007	0.5	0.1303	0.00009	1.2

↵* Calculated probability (according to Equation 1) of mono- and polyiodinated antibody fractions P_i(x).
↵^† Mono- and polyiodinated fractions (%) of all iodinated antibodies.
↵^‡ Respective probability to be radiolabeled P_a(x) (according to the Newton binome).
↵^§ Resulting fraction (by multiplication of P_i(x) with P_a(x)) of radiolabeled mono- and polyiodinated antibodies F(x).
↵^‖ The later fraction (%) of all radiolabeled antibodies.