Multiinstitutional Bone Marrow Data (131I Only)
| Patient parameters | Units | Institution: Patient number | ||||||
|---|---|---|---|---|---|---|---|---|
| A1 | B2 | F1 | G1 | |||||
| Age | y | 62 | 34 | 71 | 48 | |||
| Sex | M/F | M | F | F | M | |||
| Patient whole-body mass | kg | 85.9 | 67.7 | 58.4 | 85.9 | |||
| Hematocrit (HCT) | Decimal fraction | 0.410 | 0.396 | 0.400 | 0.410 | |||
| Adm activity | MBq | 6.08E+03 | 5.16E+03 | 3.89E+03 | 7.36E+03 | |||
| Physical t1/2 | s | 6.95E+05 | 6.95E+05 | 6.95E+05 | 6.95E+05 | |||
| AUC: blood time–activity curve; no decay to last time point | MBq-s | 1.17E+04 | 2.65E+03 | 6.15E+03 | 2.65E+03 | |||
| Fraction of activity after last time point | Fractional activity | 0.0370 | 0.0189 | 0.2920 | 0.0490 | |||
| Biologic t1/2 in blood, second exponential term | s | 3.05E+05 | 5.77E+04 | 4.05E+05 | 6.15E+04 | |||
| AUC: blood time–activity curve; no decay/extrapolation to ∞ | MBq-s | 1.23E+04 | 2.71E+03 | 1.24E+04 | 2.81E+03 | |||
| Biologic t1/2 in blood | s | 2.31E+05 | 5.08E+04 | 2.34E+05 | 5.27E+04 | |||
| t1/2eff in blood | s | 1.74E+05 | 4.73E+04 | 1.75E+05 | 4.90E+04 | |||
| Residence time in blood | s | 2.50E+05 | 6.81E+04 | 2.52E+05 | 7.05E+04 | |||
| Cumulated activity in blood per adm activity | MBq-s/MBq adm | 2.50E+05 | 6.82E+04 | 2.52E+05 | 7.05E+04 | |||
| t1/2eff for whole body | s | 1.98E+05 | 1.14E+05 | 1.67E+05 | 8.35E+04 | |||
| Cumulated activity in whole body per adm activity | MBq-s/MBq adm | 2.85E+05 | 1.65E+05 | 2.41E+05 | 1.20E+05 | |||
| Ratio of activity mass concentrations for red marrow to blood (Eq. 2) | Decimal fraction | 0.32 | 0.31 | 0.32 | 0.32 | |||
| Cumulated activity in red marrow (Eq. 3) | MBq-s/MBq adm | 2.32E+04 | 6.18E+03 | 2.30E+04 | 6.55E+03 | |||
| Reference Man red marrow mass | kg | 1.5 | 1.5 | 1.5 | 1.5 | |||
| S(RM ← RM): MIRD Pamphlet No. 11 (13) | mGy/MBq-s | 1.727E−05 | 1.727E−05 | 1.727E−05 | 1.727E−05 | |||
| S(RM ← WB): MIRD Pamphlet No. 11 (13) | mGy/MBq-s | 7.510E−07 | 7.510E−07 | 7.510E−07 | 7.510E−07 | |||
| S(RM ← RB): patient (Eq. 9b) | mGy/MBq-s | 3.892E−07 | 3.892E−07 | 3.892E−07 | 3.892E−07 | |||
| Red marrow dose per adm activity (Eq. 7) | mGy/MBq | 0.428 | 0.172 | 0.561 | 0.136 | |||
| Total absorbed dose to red marrow | mGy | 2.61E+03 | 8.89E+02 | 2.19E+03 | 1.00E+03 | |||
| Platelet toxicity | Grade (NCI) | 3 | 4 | 0 | 0 | |||
| Shift in platelets from baseline value | % | 85.7 | 98.3 | 49.1 | 62 | |||
adm = administered; NCI = National Cancer Institute.